Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

Guilin Tang; Sa A. Wang; Victoria Lu; Hans Chulhee Lee; Muzaffar H. Qazilbash; Xiaohong I. Wang; C. Cameron Yin; Robert Orlowski; Yaping Wang; Ankita Patel; L. Jeffrey Medeiros; Gary Lu

doi:10.1016/j.leukres.2014.05.015

Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

Guilin Tang, Sa A. Wang, Victoria Lu, Hans Chulhee Lee, Muzaffar H. Qazilbash, Xiaohong I. Wang, C. Cameron Yin, Robert Orlowski, Yaping Wang, Ankita Patel, L. Jeffrey Medeiros, Gary Lu

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.

Original language	English
Pages (from-to)	896-900
Number of pages	5
Journal	Leukemia Research
Volume	38
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2014.05.015
State	Published - Aug 2014
Externally published	Yes

Keywords

Bone marrow
Clonal cytogenetic abnormalities
Cytotoxic therapy
Silent
Therapy-related myeloid neoplasms

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10.1016/j.leukres.2014.05.015

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title = "Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms",

abstract = "Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically {"}silent{"}. In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically {"}silent{"} CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.",

keywords = "Bone marrow, Clonal cytogenetic abnormalities, Cytotoxic therapy, Silent, Therapy-related myeloid neoplasms",

author = "Guilin Tang and Wang, {Sa A.} and Victoria Lu and Lee, {Hans Chulhee} and Qazilbash, {Muzaffar H.} and Wang, {Xiaohong I.} and Yin, {C. Cameron} and Robert Orlowski and Yaping Wang and Ankita Patel and Medeiros, {L. Jeffrey} and Gary Lu",

year = "2014",

month = aug,

doi = "10.1016/j.leukres.2014.05.015",

language = "English",

volume = "38",

pages = "896--900",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "8",

}

TY - JOUR

T1 - Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

AU - Tang, Guilin

AU - Wang, Sa A.

AU - Lu, Victoria

AU - Lee, Hans Chulhee

AU - Qazilbash, Muzaffar H.

AU - Wang, Xiaohong I.

AU - Yin, C. Cameron

AU - Orlowski, Robert

AU - Wang, Yaping

AU - Patel, Ankita

AU - Medeiros, L. Jeffrey

AU - Lu, Gary

PY - 2014/8

Y1 - 2014/8

N2 - Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.

AB - Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.

KW - Bone marrow

KW - Clonal cytogenetic abnormalities

KW - Cytotoxic therapy

KW - Silent

KW - Therapy-related myeloid neoplasms

UR - http://www.scopus.com/inward/record.url?scp=84904550541&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2014.05.015

DO - 10.1016/j.leukres.2014.05.015

M3 - Article

C2 - 24939217

AN - SCOPUS:84904550541

SN - 0145-2126

VL - 38

SP - 896

EP - 900

JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

Abstract

Keywords

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