Clinical trial: The efficacy and safety of routine bowel cleansing agents for elective colonoscopy in persons with spinal cord injury - A randomized prospective single-blind study

H. R. Ancha, A. M. Spungen, W. A. Bauman, A. S. Rosman, S. Shaw, K. K. Hunt, J. B. Post, M. Galea, M. A. Korsten

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background As difficulty with evacuation is a common occurrence in individuals with spinal cord injury, preparation prior to colonoscopy may be suboptimal and, perhaps, more hazardous. Aim To assess the safety and efficacy of bowel cleansing regimens in persons with spinal cord injury. Methods Randomized, prospective, single blind study comparing polyethylene glycol (PEG), oral sodium phosphosoda (OSPS) and combination of both for colonic preparation prior to colonoscopy in subjects with spinal cord injury. Results Thirty six subjects with eGFR ≥60 mL/min/1.73 m2 were randomized to PEG or OSPS or PEG+OSPS. Regardless of bowel preparation employed, >73% of subjects had unacceptable colonic cleansing. No subject in the OSPS preparation group demonstrated a decrease in eGFR or an increase in serum creatinine concentration from the baseline. OSPS and PEG+OSPS preparations caused a transient change in serum potassium, phosphate and calcium concentrations, but no change in electrolytes was noted in the PEG group. Conclusions Neither OSPS alone, PEG alone nor their combination was sufficient to prepare adequately the bowel for colonoscopy in most patients with spinal cord injury. However, administration of OSPS and/or PEG appears to be safe in the spinal cord injury population, provided adequate hydration is provided.

Original languageEnglish
Pages (from-to)1110-1117
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume30
Issue number11-12
DOIs
StatePublished - Dec 2009

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