TY - JOUR
T1 - Clinical symptoms of skin, nails, and joints manifest independently in patients with concomitant psoriasis and psoriatic arthritis
AU - Wittkowski, Knut M.
AU - Leonardi, Craig
AU - Gottlieb, Alice
AU - Menter, Alan
AU - Krueger, Gerald G.
AU - Tebbey, Paul W.
AU - Belasco, Jennifer
AU - Soltani-Arabshahi, Razieh
AU - Gray, John
AU - Horn, Liz
AU - Krueger, James G.
AU - The International Psoriasis Council, International Psoriasis Council
N1 - Funding Information:
Alan Menter, M.D. has the following conflicts of interest in the form of compensation: Abbott, Allergen, Amgen, Astellas, Asubio, Celgene, Centocor, DUSA, Eli Lilly, GAlderma, Genentech, Novartis, Novo Nordisk, Pfizer, Promius, Stiefel, Syntrix Biosystems, Warner Chilcott and Wyeth. This compensation is not for employment. Gerald G Krueger, M.D. has received fees as a consultant or advisory board member for Abbott, Almirall, Alza, Amgen, Anacor, Astellas, Barrier Therapeutics, Boehringer Ingleheim, Bristol Myers Squibb, Centocor, CombinatoRx, Exelixis, Genentech, Genzyme, Isis, L'Oreal, Lupin Limited, Magen Biosciencs, MedaCorp, Medicis, Novartis, Nova Nordisc, Schering Plough, Somagenics, theDerm.org, Synvista, Warner Chilcot, UCB, USANA Health Sciences and ZARS. Dr. Krueger owns equities and stock options in/from ZARS. In the last 24 months Dr. Krueger has received lecture fees from Abbott, AMgen, Astellas, Boehringer Ingleheim, Centocor, Connetics, National Psoriasis Foundation, The Foundation for Better Health Care and Warner Chilcott. Dr. Krueger has received partial stipend support for a clinical research fellowship from Abbott, Amgen and Centocor. Paul Tebbey, PhD. is employed by the International Psoriasis Council to provide scientific advice. James G. Krueger, M.D., Ph.D. has the following conflicts of interest: Abbott, Centocor, Janssen-Cilag, Pfizer, Merch, Avontec and Magen. They are all lecture honoraria or consulting and all less than $10,000 a year. The other authors have no conflicts of interest to report. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.
PY - 2011
Y1 - 2011
N2 - This study correlated assessment tools for evaluating the severity of skin, nail, and joint symptoms in patients with psoriasis (Pso) and psoriatic arthritis (PsA). Adults with plaque Pso (with or without PsA) were enrolled from four U.S. institutions. Patients were evaluated using a novel 10-area Linear Psoriasis Area and Severity Index (XL-PASI), Psoriatic Arthritis Assessment (PsAA), Psoriatic Arthritis Screening and Evaluation Questionnaire (PASE), Nail Assessment (NA) and Joint Assessment (JA) tools, Psoriasis Weighted Extent and Severity Index (PWESI), and Lattice Physician Global Assessment (LS-PGA). Correlations between assessment tools and individual items in the assessment tools were performed. Data from 180 patients (55 with PsA) were analyzed. Highest correlations between tools (r = 0.77-0.88) were between the XL-PASI, PWESI and LS-PGA. Individual items in the XL-PASI correlated with items in the PWESI for extent skin symptoms, but not for all body areas. Overall, correlations were seen between hands and feet, between face and scalp, and between buttocks, chest, and back. Only low correlation was seen between items assessing joint symptoms with items assessing skin symptoms. These data support the notion that the complex phenotype of psoriatic disease requires instruments that assess the severity of skin, nails, and joints separately.
AB - This study correlated assessment tools for evaluating the severity of skin, nail, and joint symptoms in patients with psoriasis (Pso) and psoriatic arthritis (PsA). Adults with plaque Pso (with or without PsA) were enrolled from four U.S. institutions. Patients were evaluated using a novel 10-area Linear Psoriasis Area and Severity Index (XL-PASI), Psoriatic Arthritis Assessment (PsAA), Psoriatic Arthritis Screening and Evaluation Questionnaire (PASE), Nail Assessment (NA) and Joint Assessment (JA) tools, Psoriasis Weighted Extent and Severity Index (PWESI), and Lattice Physician Global Assessment (LS-PGA). Correlations between assessment tools and individual items in the assessment tools were performed. Data from 180 patients (55 with PsA) were analyzed. Highest correlations between tools (r = 0.77-0.88) were between the XL-PASI, PWESI and LS-PGA. Individual items in the XL-PASI correlated with items in the PWESI for extent skin symptoms, but not for all body areas. Overall, correlations were seen between hands and feet, between face and scalp, and between buttocks, chest, and back. Only low correlation was seen between items assessing joint symptoms with items assessing skin symptoms. These data support the notion that the complex phenotype of psoriatic disease requires instruments that assess the severity of skin, nails, and joints separately.
UR - https://www.scopus.com/pages/publications/79957853898
U2 - 10.1371/journal.pone.0020279
DO - 10.1371/journal.pone.0020279
M3 - Article
C2 - 21673809
AN - SCOPUS:79957853898
SN - 1932-6203
VL - 6
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e20279
ER -