Clinical Signs of the Pseudoexfoliation Syndrome

Andrew M. Prince, Robert Ritch

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


Pseudoexfoliation syndrome (PXS) is a common cause of glaucoma throughout the world. It is most commonly diagnosed after the observation of pseudoexfoliation material (PXIVI) on the anterior lens surface. However, there are numerous clinical signs of PXS that should alert the examiner to search carefully for PXIVI on the anterior lens surface. These include pupillary ruff defects, iris sphincter transillumination, a characteristic whorl-like pattern of particulate pigment deposition on the iris sphincter, particulate pigment deposition on the peripheral iris and trabecular meshwork, and exfoliation material on the zonules and ciliary body. Accuracy of diagnosis is important for purposes of treatment, prognosis, and basic research in the mechanisms of glaucoma, particularly tissue culture.

Original languageEnglish
Pages (from-to)803-807
Number of pages5
Issue number6
StatePublished - 1986
Externally publishedYes


  • glaucoma
  • iris
  • pigmentation
  • pseudoexfoliation syndrome
  • pupil
  • trabecular meshwork


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