Clinical significance of activated protein C resistance as a potential marker for hypercoagulable state

Toshiyuki Sakata; Kazuomi Kario; Yoshiaki Katayama; Tatsuo Matsuyama; Hisao Kato; Toshiyuki Miyata

doi:10.1016/0049-3848(96)00070-9

Clinical significance of activated protein C resistance as a potential marker for hypercoagulable state

Toshiyuki Sakata, Kazuomi Kario, Yoshiaki Katayama, Tatsuo Matsuyama, Hisao Kato, Toshiyuki Miyata

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23 Scopus citations

Abstract

The activated protein G (APC)-resistance test is a simple and reliable method for detecting reduced sensitivity to the anticoagulant action of this protein. We investigated the sensitivity to APC in 180 Japanese controls and in 96 Japanese patients with venous and arterial thrombosis (28 with deep vein thrombosis; 13 with pulmonary thromboembolism; 41 with cerebral infarction; and 14 with coronary artery disease). All of the patient groups showed significantly reduced sensitivity to APC, reflected by the lower normalized APC-sensitivity ratio (n-APC-SR), as compared with healthy control. The APC-sensitivity ratio was negatively correlated with plasma activated factor VII levels. These results suggest that the low n-APC-SR is related to venous or arterial thrombotic disease. The APC resistance may serve as a potential marker for assessing the hypercoagulable state.

Original language	English
Pages (from-to)	235-244
Number of pages	10
Journal	Thrombosis Research
Volume	82
Issue number	3
DOIs	https://doi.org/10.1016/0049-3848(96)00070-9
State	Published - 1 May 1996
Externally published	Yes

Keywords

APC resistance
Activated factor VII
Hypercoagulable state
Normalized APC-sensitivity ratio
Thrombosis

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10.1016/0049-3848(96)00070-9

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title = "Clinical significance of activated protein C resistance as a potential marker for hypercoagulable state",

abstract = "The activated protein G (APC)-resistance test is a simple and reliable method for detecting reduced sensitivity to the anticoagulant action of this protein. We investigated the sensitivity to APC in 180 Japanese controls and in 96 Japanese patients with venous and arterial thrombosis (28 with deep vein thrombosis; 13 with pulmonary thromboembolism; 41 with cerebral infarction; and 14 with coronary artery disease). All of the patient groups showed significantly reduced sensitivity to APC, reflected by the lower normalized APC-sensitivity ratio (n-APC-SR), as compared with healthy control. The APC-sensitivity ratio was negatively correlated with plasma activated factor VII levels. These results suggest that the low n-APC-SR is related to venous or arterial thrombotic disease. The APC resistance may serve as a potential marker for assessing the hypercoagulable state.",

keywords = "APC resistance, Activated factor VII, Hypercoagulable state, Normalized APC-sensitivity ratio, Thrombosis",

author = "Toshiyuki Sakata and Kazuomi Kario and Yoshiaki Katayama and Tatsuo Matsuyama and Hisao Kato and Toshiyuki Miyata",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from Minist~ of Education, Science, Sports and Culture of Japan, Special Coordination Funds for Promoting Science and Technology (Encouragement System of COE), the Science and Technology Agency of Japan, and Kato Memorial Bioscience Foundation.",

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doi = "10.1016/0049-3848(96)00070-9",

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AU - Kario, Kazuomi

AU - Katayama, Yoshiaki

AU - Matsuyama, Tatsuo

AU - Kato, Hisao

AU - Miyata, Toshiyuki

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from Minist~ of Education, Science, Sports and Culture of Japan, Special Coordination Funds for Promoting Science and Technology (Encouragement System of COE), the Science and Technology Agency of Japan, and Kato Memorial Bioscience Foundation.

PY - 1996/5/1

Y1 - 1996/5/1

N2 - The activated protein G (APC)-resistance test is a simple and reliable method for detecting reduced sensitivity to the anticoagulant action of this protein. We investigated the sensitivity to APC in 180 Japanese controls and in 96 Japanese patients with venous and arterial thrombosis (28 with deep vein thrombosis; 13 with pulmonary thromboembolism; 41 with cerebral infarction; and 14 with coronary artery disease). All of the patient groups showed significantly reduced sensitivity to APC, reflected by the lower normalized APC-sensitivity ratio (n-APC-SR), as compared with healthy control. The APC-sensitivity ratio was negatively correlated with plasma activated factor VII levels. These results suggest that the low n-APC-SR is related to venous or arterial thrombotic disease. The APC resistance may serve as a potential marker for assessing the hypercoagulable state.

AB - The activated protein G (APC)-resistance test is a simple and reliable method for detecting reduced sensitivity to the anticoagulant action of this protein. We investigated the sensitivity to APC in 180 Japanese controls and in 96 Japanese patients with venous and arterial thrombosis (28 with deep vein thrombosis; 13 with pulmonary thromboembolism; 41 with cerebral infarction; and 14 with coronary artery disease). All of the patient groups showed significantly reduced sensitivity to APC, reflected by the lower normalized APC-sensitivity ratio (n-APC-SR), as compared with healthy control. The APC-sensitivity ratio was negatively correlated with plasma activated factor VII levels. These results suggest that the low n-APC-SR is related to venous or arterial thrombotic disease. The APC resistance may serve as a potential marker for assessing the hypercoagulable state.

KW - APC resistance

KW - Activated factor VII

KW - Hypercoagulable state

KW - Normalized APC-sensitivity ratio

KW - Thrombosis

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Clinical significance of activated protein C resistance as a potential marker for hypercoagulable state

Abstract

Keywords

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