Clinical research design: From observational research to clinical trials

Eve Aymong, George Danges, Dale Ashby, Roxana Mehran

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Clinical research is performed in an attempt to learn about the effects of a phenomenon in a specific population under study and extrapolate that knowledge to the truth of its effect in nature. For practical reasons, a sample of the entire population is chosen to represent the larger population of interest. In other words, the sample is chosen in a way that the results can be generalized to the larger population. This goal can be accomplished with techniques such as observational studies (cohort and crossover designs) as well as clinical trials involving an intervention, especially randomized trials with their variations and complexities.

Original languageEnglish
Title of host publicationClinical, Interventional and Investigational Thrombocardiology
PublisherCRC Press
Number of pages16
ISBN (Electronic)9780849344954
ISBN (Print)0824754190, 9780824754198
StatePublished - 1 Jan 2005
Externally publishedYes


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