TY - JOUR
T1 - Clinical Relevance of Skin Pain in Atopic Dermatitis
AU - Ständer, Sonja
AU - Simpson, Eric L.
AU - Guttman-Yassky, Emma
AU - Thyssen, Jacob P.
AU - Kabashima, Kenji
AU - Ball, Susan G.
AU - Rueda, Maria Jose
AU - DeLozier, Amy M.
AU - Silverberg, Jonathan I.
N1 - Publisher Copyright:
© 2020 Journal of Drugs in Dermatology. All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Skin pain is increasingly recognized as an impactful symptom in atopic dermatitis (AD) because of its association with patient discomfort, disease burden, and reduced quality of life. Although the nature of skin pain in AD has not been systematically studied and is therefore not well understood, patients report soreness, discomfort, and tenderness that may reflect peripheral and central pain sensitization. The high prevalence of skin pain suggests that it is not adequately addressed by current therapies for AD and may be undertreated compared with other symptoms. This review discusses the clinical relevance of skin pain with respect to its experience, pathophysiology, relationship with itch, and treatment implications. Recent studies suggest that skin pain presents as a neuropathic symptom independent from itch and the “itch-scratch cycle”, and poses a unique burden to patients. Recognition of the significant consequences of skin pain and discomfort should reinforce the need to assess and treat this symptom in patients with moderate-to-severe AD.
AB - Skin pain is increasingly recognized as an impactful symptom in atopic dermatitis (AD) because of its association with patient discomfort, disease burden, and reduced quality of life. Although the nature of skin pain in AD has not been systematically studied and is therefore not well understood, patients report soreness, discomfort, and tenderness that may reflect peripheral and central pain sensitization. The high prevalence of skin pain suggests that it is not adequately addressed by current therapies for AD and may be undertreated compared with other symptoms. This review discusses the clinical relevance of skin pain with respect to its experience, pathophysiology, relationship with itch, and treatment implications. Recent studies suggest that skin pain presents as a neuropathic symptom independent from itch and the “itch-scratch cycle”, and poses a unique burden to patients. Recognition of the significant consequences of skin pain and discomfort should reinforce the need to assess and treat this symptom in patients with moderate-to-severe AD.
UR - http://www.scopus.com/inward/record.url?scp=85092684204&partnerID=8YFLogxK
U2 - 10.36849/JDD.2020.5498
DO - 10.36849/JDD.2020.5498
M3 - Article
C2 - 33026764
AN - SCOPUS:85092684204
SN - 1545-9616
VL - 19
SP - 921
EP - 926
JO - Journal of Drugs in Dermatology
JF - Journal of Drugs in Dermatology
IS - 10
ER -