Clinical preparation—subject recruitment

Brianna M. Jones, Kristin Hsieh, Daniel R. Dickstein, Eric J. Lehrer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Randomized controlled trials are essential to improving patient outcomes; however, recruitment is a barrier to successful trial completion. Poor subject recruitment∗ and retention∗ limit generalizability, reliability, external validity and increase risk of type II error∗ and costs/resources). 1 Studies suggest that less than a third of trials achieve initial recruitment targets and require extension and/or additional funds. 2–4 Recruitment that includes a diverse population such as racial/ethnic minority groups, women, elderly, LGBTQ+members and vulnerable populations such as those living with HIV/AIDS is crucial to allow generalizability and minimization of health disparities in treatment outcomes. There are a multitude of barriers to successful recruitment to RCTs including lack of pre-trial planning, inadequate community outreach efforts, complex study trial design, restrictive eligibility criteria, and sociocultural barriers. In this chapter, we discuss interventions to improve subject recruitment and retention based on contemporary studies.

Original languageEnglish
Title of host publicationTranslational Radiation Oncology
PublisherElsevier
Pages409-417
Number of pages9
ISBN (Electronic)9780323884235
ISBN (Print)9780323884242
DOIs
StatePublished - 1 Jan 2023

Keywords

  • Community outreach
  • Patient contact
  • Recruitment
  • Retention
  • Sociocultural barriers
  • Trial design

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