Clinical Pharmacological Trial of Guanazole

Daniel Yakar; James F. Holland; Rose Ruth Ellison; Arnold Freeman

Clinical Pharmacological Trial of Guanazole

Daniel Yakar
, James F. Holland
, Rose Ruth Ellison
, Arnold Freeman

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Guanazole was given to 27 patients with advanced neoplastic diseases, mostly acute leukemia, by continuous i.v. infusion in 5-day courses. Toxicity was manifest mainly by myelosuppression, but drug fever, mucositis, rash, and alkalosis were also observed. Complete remission was achieved in two out of 14 patients with previously treated acute myelocytic leukemia, and an M1 marrow occurred in one out of four patients with advanced acute lymphocytic leukemia. Most of the effects of guanazole appear to be dose related, with a narrow therapeutic index. This is the first evidence of therapeutic activity of guanazole in man.

Original language	English
Pages (from-to)	972-975
Number of pages	4
Journal	Cancer Research
Volume	33
Issue number	5
State	Published - May 1973
Externally published	Yes

Cite this

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title = "Clinical Pharmacological Trial of Guanazole",

abstract = "Guanazole was given to 27 patients with advanced neoplastic diseases, mostly acute leukemia, by continuous i.v. infusion in 5-day courses. Toxicity was manifest mainly by myelosuppression, but drug fever, mucositis, rash, and alkalosis were also observed. Complete remission was achieved in two out of 14 patients with previously treated acute myelocytic leukemia, and an M1 marrow occurred in one out of four patients with advanced acute lymphocytic leukemia. Most of the effects of guanazole appear to be dose related, with a narrow therapeutic index. This is the first evidence of therapeutic activity of guanazole in man.",

author = "Daniel Yakar and Holland, \{James F.\} and Ellison, \{Rose Ruth\} and Arnold Freeman",

year = "1973",

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T1 - Clinical Pharmacological Trial of Guanazole

AU - Yakar, Daniel

AU - Holland, James F.

AU - Ellison, Rose Ruth

AU - Freeman, Arnold

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N2 - Guanazole was given to 27 patients with advanced neoplastic diseases, mostly acute leukemia, by continuous i.v. infusion in 5-day courses. Toxicity was manifest mainly by myelosuppression, but drug fever, mucositis, rash, and alkalosis were also observed. Complete remission was achieved in two out of 14 patients with previously treated acute myelocytic leukemia, and an M1 marrow occurred in one out of four patients with advanced acute lymphocytic leukemia. Most of the effects of guanazole appear to be dose related, with a narrow therapeutic index. This is the first evidence of therapeutic activity of guanazole in man.

AB - Guanazole was given to 27 patients with advanced neoplastic diseases, mostly acute leukemia, by continuous i.v. infusion in 5-day courses. Toxicity was manifest mainly by myelosuppression, but drug fever, mucositis, rash, and alkalosis were also observed. Complete remission was achieved in two out of 14 patients with previously treated acute myelocytic leukemia, and an M1 marrow occurred in one out of four patients with advanced acute lymphocytic leukemia. Most of the effects of guanazole appear to be dose related, with a narrow therapeutic index. This is the first evidence of therapeutic activity of guanazole in man.

UR - https://www.scopus.com/pages/publications/0015621622

M3 - Article

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SN - 0008-5472

VL - 33

SP - 972

EP - 975

JO - Cancer Research

JF - Cancer Research

IS - 5

ER -

Clinical Pharmacological Trial of Guanazole

Abstract

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