Clinical outcomes of radiofrequency catheter ablation of ventricular tachycardia in patients with hypertrophic cardiomyopathy

Jalaj Garg, Jakrin Kewcharoen, Kuldeep Shah, Mohit Turagam, Rahul Bhardwaj, Tahmeed Contractor, Ravi Mandapati, Dhanunjaya Lakkireddy

Research output: Contribution to journalArticlepeer-review


Background: Monomorphic ventricular tachycardia (VT) is rare in patients with hypertrophic cardiomyopathy (HCM), management of which is challenging. Limited data exists on the utility of catheter ablation for the treatment of VT in this population. Objectives: We aimed to assess clinical outcomes of catheter ablation for VT in HCM patients. Methods: A systematic search, without language restriction, using PubMed, EMBASE, SCOPUS, Google Scholar, and was performed. The meta-analysis was performed using a meta-package for R version 4.0/RStudio version 1.2 and Freeman Tukey double arcsine method to establish the variance of raw proportions. Outcomes measured included (1) acute procedure success (defined as noninducible for clinical VT), (2) freedom from VT at follow-up, (3) mortality. Results: This systematic review of six studies (three from the United States and three from Japan) incorporated a total of 68 drug-refractory HCM patients who underwent VT radiofrequency catheter ablation (mean age 57.6 ± 13.3 years, mean LVEF 45.8 ± 15.4%, 85% men, maximum septal wall thickness 17.4 ± 4.6 mm, and 32.3% with an apical aneurysm). Acute procedural success was achieved in 84.5% patients (95% confidence interval [CI]: 70.6%–95.2%) with 27.9% patients had recurrent VT requiring multiple ablations (median 1, IQR 1–3). During the follow-up period (18.3 ± 11.7 months), the pooled incidence of freedom from recurrent VT after index procedure was 70.2% (95% CI: 51.9%–86.2%), while after the last ablation was 82.8% (95% CI: 57%–99.2%). There were two deaths during follow-up, one from heart failure and one from SCD 0.8% (95% CI: 0%–5.8%). Conclusion: The results of our pooled analysis demonstrated that catheter ablation for VT in HCM patients was associated with high acute procedural success, and reduced VT recurrence—findings comparable to previously published reports in other disease substrates.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Issue number1
StatePublished - Jan 2023


  • catheter ablation
  • death
  • hypertrophic cardiomyopathy
  • ventricular tachycardia


Dive into the research topics of 'Clinical outcomes of radiofrequency catheter ablation of ventricular tachycardia in patients with hypertrophic cardiomyopathy'. Together they form a unique fingerprint.

Cite this