Clinical outcomes and immunologic characteristics of coronavirus disease 2019 in people with human immunodeficiency virus

Hsi En Ho, Michael J. Peluso, Colton Margus, Joao Pedro Matias Lopes, Chen He, Michael M. Gaisa, Georgina Osorio, Judith A. Aberg, Michael P. Mullen

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

We performed a retrospective study of coronavirus disease 2019 (COVID-19) in people with human immunodeficiency virus (PWH). PWH with COVID-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin 6, interleukin 8, and tumor necrosis factor α were commonly elevated. In all, 19 of 72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of COVID-19 despite antiretroviral therapy and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.

Original languageEnglish
Pages (from-to)403-408
Number of pages6
JournalJournal of Infectious Diseases
Volume223
Issue number3
DOIs
StatePublished - 1 Feb 2021

Keywords

  • COVID-19
  • HIV
  • SARS-CoV-2
  • coronavirus
  • inflammation
  • people living with HIV

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