Clinical Outcome of Double Kissing Crush Versus Provisional Stenting of Coronary Artery Bifurcation Lesions

Shao Liang Chen, Teguh Santoso, Jun Jie Zhang, Fei Ye, Ya Wei Xu, Qiang Fu, Jing Kan, Feng Fu Zhang, Yong Zhou, Du Jiang Xie, Tak W. Kwan

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Background - Provisional stenting is effective for anatomic simple bifurcation lesions. Double kissing crush stenting reduces the 1-year rate of target lesion revascularization. This study aimed to investigate the 5-year clinical results of the DKCRUSH-II study (Randomized Study on Double Kissing Crush Technique Versus Provisional Stenting Technique for Coronary Artery Bifurcation Lesions). Methods and Results - A total of 370 patients with coronary bifurcation lesions who were randomly assigned to either the double kissing crush or provisional stenting group in the DKCRUSH-II study were followed for 5 years. The primary end point was the occurrence of a major adverse cardiac event at 5 years. Patients were classified by simple and complex bifurcation lesions according to the DEFINITION criteria (Definitions and Impact of Complex Bifurcation Lesions on Clinical Outcomes After Percutaneous Coronary Intervention Using Drug-Eluting Stents). At 5 years, the major adverse cardiac event rate (23.8%) in the provisional stenting group was insignificantly different to that of the double kissing group (15.7%; P=0.051). However, the difference in the target lesion revascularization rate between 2 groups was sustained through the 5-year follow-up (16.2% versus 8.6%; P=0.027). The definite and probable stent thrombosis rate was 2.7% in each group (P=1.0). Complex bifurcation was associated with a higher rate of target lesion revascularization (21.6%) at 5 years compared with 11.1% in patients with a simple bifurcation (P=0.037), with an extremely high rate in the provisional stenting group (36.8% versus 12.5%, P=0.005) mainly because of final kissing balloon inflation (19.4% versus 5.2%; P=0.036). Conclusions - The double kissing crush stenting technique for coronary bifurcation lesions is associated with a lower rate of target lesion revascularization. The optimal stenting approach based on the lesions' complexity may improve the revascularization for patients with complex bifurcations. Clinical Trial Registration - URL: http://www.chictr.org. Unique identifier: ChiCTR-TRC-0000015.

Original languageEnglish
Article numbere004497
JournalCirculation: Cardiovascular Interventions
Volume10
Issue number2
DOIs
StatePublished - 1 Feb 2017
Externally publishedYes

Keywords

  • angiography
  • aspirin
  • coronary artery bifurcation lesions
  • double kissing crush
  • myocardial infarction
  • stents
  • thrombosis

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