TY - JOUR
T1 - Clinical outcome after surgical resection of lung metastases from melanoma
AU - Conilla, Carlos
AU - Gimferrer, José María
AU - Marruecos, Jordi
AU - Domingo-Domènech, Josep
AU - Vilella, Ramó
AU - Catalán, Miquel
AU - Malvehy, Josep
AU - Puig, Susana
AU - Castel, Teresa
PY - 2007
Y1 - 2007
N2 - Background. Surgical therapy plays an important role in the management of selected patients with metastatic melanoma. Purpose. A retrospective review of 13 patients who underwent surgical resection of lung metastases from melanoma from 1996 to 2003 was performed. The aim of the study was to analyze the clinical outcome and survival time. Materials and methods. Mean age was 45 years old (range:31-64). Complete tumour resection was confir med histologically. Nine patients presented one single pulmonary lesion, two lesions (n = 3) and three lesions (n = 1) but in all cases confined in the same pulmonary lobe. Results. Median survival time (MST) for the entire group was 20 months (95% confidence interval (CI): 16-24 months). The median time to disease progression after lung metastasectomy was 5 months (95% CI: 3-7 months). MST, according to the prognostic groups proposed by the International Registry of Lung Metastases, was 17 months (95% CI: 6-28 months) for group I (n = 6), MST of 20 months (95% CI: 16-24 months) for group II (n = 5) and MST of 4 months for group III (n = 2), without differences statistically significant (log-rank p = 0.423). MST regarding the time of disease free interval from diagnostic of primary tumour and lung metastases (< 36 months [n = 5] vs > 36 months [n = 8]) was 20 months and 17 months respectively, without differences statistically significant (log rank p = 0.222). Conclusions. Surgical resection when feasible provides survival rates superior to any available nonsurgical therapy. In carefully selected patients, when the resection is performed with curative intent, it may result in improved survival.
AB - Background. Surgical therapy plays an important role in the management of selected patients with metastatic melanoma. Purpose. A retrospective review of 13 patients who underwent surgical resection of lung metastases from melanoma from 1996 to 2003 was performed. The aim of the study was to analyze the clinical outcome and survival time. Materials and methods. Mean age was 45 years old (range:31-64). Complete tumour resection was confir med histologically. Nine patients presented one single pulmonary lesion, two lesions (n = 3) and three lesions (n = 1) but in all cases confined in the same pulmonary lobe. Results. Median survival time (MST) for the entire group was 20 months (95% confidence interval (CI): 16-24 months). The median time to disease progression after lung metastasectomy was 5 months (95% CI: 3-7 months). MST, according to the prognostic groups proposed by the International Registry of Lung Metastases, was 17 months (95% CI: 6-28 months) for group I (n = 6), MST of 20 months (95% CI: 16-24 months) for group II (n = 5) and MST of 4 months for group III (n = 2), without differences statistically significant (log-rank p = 0.423). MST regarding the time of disease free interval from diagnostic of primary tumour and lung metastases (< 36 months [n = 5] vs > 36 months [n = 8]) was 20 months and 17 months respectively, without differences statistically significant (log rank p = 0.222). Conclusions. Surgical resection when feasible provides survival rates superior to any available nonsurgical therapy. In carefully selected patients, when the resection is performed with curative intent, it may result in improved survival.
KW - Lung
KW - Melanoma
KW - Metastasis
KW - Surgery Treatment
UR - http://www.scopus.com/inward/record.url?scp=34547600024&partnerID=8YFLogxK
U2 - 10.1007/s12094-007-0009-4
DO - 10.1007/s12094-007-0009-4
M3 - Article
C2 - 17272230
AN - SCOPUS:34547600024
SN - 1699-048X
VL - 9
SP - 48
EP - 52
JO - Clinical and Translational Oncology
JF - Clinical and Translational Oncology
IS - 1
ER -