Clinical manifestations of ocular toxoplasmosis

Emmanuelle Delair, Paul Latkany, A. Gwendolyn Noble, Peter Rabiah, Rima McLeod, Antoine Brézin

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Clinical manifestations of ocular toxoplasmosis are reviewed. Findings of congenital and acute acquired ocular toxoplasmosis include retinal scars, white-appearing lesions in the active phase often associated with vitritis. Complications can include fibrous bands, secondary serous or rhegmatogenous retinal detachments, optic neuritis and neuropathy, cataracts, increased intraocular pressure during active infection, and choroidal neovascular membranes. Recurrences in untreated congenital toxoplasmosis occur in teenage years. Manifestations at birth are less severe, and recurrences are fewer in those who were treated promptly early in the course of their disease in utero and in the first year of life. Severe retinal involvement is common at diagnosis of symptomatic congenital toxoplasmosis in the United States and Brazil. Acute acquired infections also may be complicated by toxoplasmic retinochoroiditis, with recurrences most common close to the time of acquisition. Suppressive treatment can reduce recurrent disease.

Original languageEnglish
Pages (from-to)91-102
Number of pages12
JournalOcular Immunology and Inflammation
Volume19
Issue number2
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • CNVM
  • Toxoplasma gondii
  • congenital toxoplasmosis
  • rétinal choriditis
  • uveitis

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