TY - JOUR
T1 - Clinical Management of Children and Adolescents with Neurofibromatosis Type 1 like Phenotypes and Complex Behavioural Manifestations
T2 - A Multidisciplinary and Dimensional Approach
AU - Moscoso, Ana
AU - Julien, Aurélie
AU - Tanet, Antoine
AU - Consoli, Angèle
AU - Pagnard, Martine
AU - Trevisan, France
AU - Kemlin, Isabelle
AU - Rodriguez, Diana
AU - Cohen, David
N1 - Publisher Copyright:
© 2019 Ana Moscoso et al.
PY - 2019
Y1 - 2019
N2 - Introduction. Cognitive and behavioural problems associated with Neurofibromatosis type 1 (NF1) are common sources of distress and the reasons behind seeking help. Here we describe patients with NF1 or NF1-like phenotypes referred to a Tier 3 Child and Adolescent Psychiatry Department and highlight the benefits of a multidisciplinary assessment. Methods. Prospective data were gathered from NF1 patients aged 7-15 years, referred by the NF1 Referral Centre due to additional difficulties either in management or diagnosis. For the selected cases, we performed a psychiatric assessment, a tailored neuropsychological evaluation based on clinical demands and history, broad speech and motor skills evaluations if there were concerns regarding language, motor abilities and/or learning difficulties and autism specific evaluations, if clinically relevant. No exclusion criteria were applied. Results. Complex NF1 cases represented only 5% of the patients (11/224). Assessments revealed the complexity of NF1 phenotype and a variety of problems including learning difficulties, emotional problems and autism spectrum disorders. Specific evaluations of language, motor, attentional and neurovisual domains were essential to guide tailored intervention strategies. Conclusions. In terms of clinical implications, the heterogeneity of NF1 phenotypical manifestations needs to be considered when developing assessment and remediation approaches for children with complex NF1.
AB - Introduction. Cognitive and behavioural problems associated with Neurofibromatosis type 1 (NF1) are common sources of distress and the reasons behind seeking help. Here we describe patients with NF1 or NF1-like phenotypes referred to a Tier 3 Child and Adolescent Psychiatry Department and highlight the benefits of a multidisciplinary assessment. Methods. Prospective data were gathered from NF1 patients aged 7-15 years, referred by the NF1 Referral Centre due to additional difficulties either in management or diagnosis. For the selected cases, we performed a psychiatric assessment, a tailored neuropsychological evaluation based on clinical demands and history, broad speech and motor skills evaluations if there were concerns regarding language, motor abilities and/or learning difficulties and autism specific evaluations, if clinically relevant. No exclusion criteria were applied. Results. Complex NF1 cases represented only 5% of the patients (11/224). Assessments revealed the complexity of NF1 phenotype and a variety of problems including learning difficulties, emotional problems and autism spectrum disorders. Specific evaluations of language, motor, attentional and neurovisual domains were essential to guide tailored intervention strategies. Conclusions. In terms of clinical implications, the heterogeneity of NF1 phenotypical manifestations needs to be considered when developing assessment and remediation approaches for children with complex NF1.
UR - http://www.scopus.com/inward/record.url?scp=85077983208&partnerID=8YFLogxK
U2 - 10.1155/2019/4764031
DO - 10.1155/2019/4764031
M3 - Article
AN - SCOPUS:85077983208
SN - 2090-682X
VL - 2019
JO - Case Reports in Psychiatry
JF - Case Reports in Psychiatry
M1 - 4764031
ER -