Clinical impact of cachexia in head and neck cancer patients who received chemoradiotherapy

Naomi Hayashi; Yasuyoshi Sato; Yu Fujiwara; Naoki Fukuda; Xiaofei Wang; Kenji Nakano; Testuya Urasaki; Akihiro Ohmoto; Makiko Ono; Junichi Tomomatsu; Yukiko Sato; Hiroki Mitani; Takashi Toshiyasu; Shunji Takahashi

doi:10.2147/CMAR.S329581

Clinical impact of cachexia in head and neck cancer patients who received chemoradiotherapy

Naomi Hayashi, Yasuyoshi Sato, Yu Fujiwara, Naoki Fukuda, Xiaofei Wang, Kenji Nakano, Testuya Urasaki, Akihiro Ohmoto, Makiko Ono, Junichi Tomomatsu, Yukiko Sato, Hiroki Mitani, Takashi Toshiyasu, Shunji Takahashi

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Purpose: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer. Patients and Methods: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients. Results: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of <4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting. Conclusion: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemora-diotherapy may improve survival in these patients.

Original language	English
Pages (from-to)	8377-8385
Number of pages	9
Journal	Cancer Management and Research
Volume	13
DOIs	https://doi.org/10.2147/CMAR.S329581
State	Published - 2021

Keywords

Cachexia
Chemoradiotherapy
Head and neck cancer
Muscle
Prognosis
Sarcopenia
Skeletal
Squamous cell carcinoma of head and neck

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10.2147/CMAR.S329581

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title = "Clinical impact of cachexia in head and neck cancer patients who received chemoradiotherapy",

abstract = "Purpose: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer. Patients and Methods: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients. Results: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of <4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting. Conclusion: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemora-diotherapy may improve survival in these patients.",

keywords = "Cachexia, Chemoradiotherapy, Head and neck cancer, Muscle, Prognosis, Sarcopenia, Skeletal, Squamous cell carcinoma of head and neck",

author = "Naomi Hayashi and Yasuyoshi Sato and Yu Fujiwara and Naoki Fukuda and Xiaofei Wang and Kenji Nakano and Testuya Urasaki and Akihiro Ohmoto and Makiko Ono and Junichi Tomomatsu and Yukiko Sato and Hiroki Mitani and Takashi Toshiyasu and Shunji Takahashi",

note = "Publisher Copyright: {\textcopyright} 2021 Hayashi et al.",

year = "2021",

doi = "10.2147/CMAR.S329581",

language = "English",

volume = "13",

pages = "8377--8385",

journal = "Cancer Management and Research",

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TY - JOUR

T1 - Clinical impact of cachexia in head and neck cancer patients who received chemoradiotherapy

AU - Hayashi, Naomi

AU - Sato, Yasuyoshi

AU - Fujiwara, Yu

AU - Fukuda, Naoki

AU - Wang, Xiaofei

AU - Nakano, Kenji

AU - Urasaki, Testuya

AU - Ohmoto, Akihiro

AU - Ono, Makiko

AU - Tomomatsu, Junichi

AU - Sato, Yukiko

AU - Mitani, Hiroki

AU - Toshiyasu, Takashi

AU - Takahashi, Shunji

PY - 2021

Y1 - 2021

N2 - Purpose: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer. Patients and Methods: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients. Results: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of <4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting. Conclusion: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemora-diotherapy may improve survival in these patients.

AB - Purpose: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer. Patients and Methods: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients. Results: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of <4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting. Conclusion: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemora-diotherapy may improve survival in these patients.

KW - Cachexia

KW - Chemoradiotherapy

KW - Head and neck cancer

KW - Muscle

KW - Prognosis

KW - Sarcopenia

KW - Skeletal

KW - Squamous cell carcinoma of head and neck

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U2 - 10.2147/CMAR.S329581

DO - 10.2147/CMAR.S329581

M3 - Article

AN - SCOPUS:85119134458

SN - 1179-1322

VL - 13

SP - 8377

EP - 8385

JO - Cancer Management and Research

JF - Cancer Management and Research

ER -

Clinical impact of cachexia in head and neck cancer patients who received chemoradiotherapy

Abstract

Keywords

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