Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler

Ellen S. Marmur; Robert Phelps; David J. Goldberg

doi:10.1080/147641704100003048

Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler

Ellen S. Marmur, Robert Phelps, David J. Goldberg

Research output: Contribution to journal › Article › peer-review

196 Scopus citations

Abstract

BACKGROUND: Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers. OBJECTIVE: We have, in this pilot study, evaluated the clinical, histologic and electron microscopic ultrastructural changes seen with CaHa at 1 and 6 months after skin injection. METHODS: Each of the three subjects was injected in the postauricular area with 0.1 cc of CaHa gel. A 3-mm punch tissue biopsy was taken at 1 and 6 months post-injection. Biopsies were analyzed by histopathology and electron microscopy. Clinical results after injection of the nasolabial folds were also evaluated. RESULTS: CaHa particles were found to persist at 6 months with evidence of new collagen formation being seen. Patients still showed clinical improvement at this time. CONCLUSION: This study is the first in vivo ultrastructural analysis of the biologic response to CaHa in human skin. CaHa shows clinical, histologic and electron microscopic evidence of persistence at 6 months.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	Journal of Cosmetic and Laser Therapy
Volume	6
Issue number	4
DOIs	https://doi.org/10.1080/147641704100003048
State	Published - Dec 2004

Keywords

Calcium hydroxylapatite
Dermal filler

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10.1080/147641704100003048

Cite this

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title = "Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler",

abstract = "BACKGROUND: Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers. OBJECTIVE: We have, in this pilot study, evaluated the clinical, histologic and electron microscopic ultrastructural changes seen with CaHa at 1 and 6 months after skin injection. METHODS: Each of the three subjects was injected in the postauricular area with 0.1 cc of CaHa gel. A 3-mm punch tissue biopsy was taken at 1 and 6 months post-injection. Biopsies were analyzed by histopathology and electron microscopy. Clinical results after injection of the nasolabial folds were also evaluated. RESULTS: CaHa particles were found to persist at 6 months with evidence of new collagen formation being seen. Patients still showed clinical improvement at this time. CONCLUSION: This study is the first in vivo ultrastructural analysis of the biologic response to CaHa in human skin. CaHa shows clinical, histologic and electron microscopic evidence of persistence at 6 months.",

keywords = "Calcium hydroxylapatite, Dermal filler",

author = "Marmur, \{Ellen S.\} and Robert Phelps and Goldberg, \{David J.\}",

year = "2004",

month = dec,

doi = "10.1080/147641704100003048",

language = "English",

volume = "6",

pages = "223--226",

journal = "Journal of Cosmetic and Laser Therapy",

issn = "1476-4172",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler

AU - Marmur, Ellen S.

AU - Phelps, Robert

AU - Goldberg, David J.

PY - 2004/12

Y1 - 2004/12

N2 - BACKGROUND: Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers. OBJECTIVE: We have, in this pilot study, evaluated the clinical, histologic and electron microscopic ultrastructural changes seen with CaHa at 1 and 6 months after skin injection. METHODS: Each of the three subjects was injected in the postauricular area with 0.1 cc of CaHa gel. A 3-mm punch tissue biopsy was taken at 1 and 6 months post-injection. Biopsies were analyzed by histopathology and electron microscopy. Clinical results after injection of the nasolabial folds were also evaluated. RESULTS: CaHa particles were found to persist at 6 months with evidence of new collagen formation being seen. Patients still showed clinical improvement at this time. CONCLUSION: This study is the first in vivo ultrastructural analysis of the biologic response to CaHa in human skin. CaHa shows clinical, histologic and electron microscopic evidence of persistence at 6 months.

AB - BACKGROUND: Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers. OBJECTIVE: We have, in this pilot study, evaluated the clinical, histologic and electron microscopic ultrastructural changes seen with CaHa at 1 and 6 months after skin injection. METHODS: Each of the three subjects was injected in the postauricular area with 0.1 cc of CaHa gel. A 3-mm punch tissue biopsy was taken at 1 and 6 months post-injection. Biopsies were analyzed by histopathology and electron microscopy. Clinical results after injection of the nasolabial folds were also evaluated. RESULTS: CaHa particles were found to persist at 6 months with evidence of new collagen formation being seen. Patients still showed clinical improvement at this time. CONCLUSION: This study is the first in vivo ultrastructural analysis of the biologic response to CaHa in human skin. CaHa shows clinical, histologic and electron microscopic evidence of persistence at 6 months.

KW - Calcium hydroxylapatite

KW - Dermal filler

UR - https://www.scopus.com/pages/publications/17444397718

U2 - 10.1080/147641704100003048

DO - 10.1080/147641704100003048

M3 - Article

C2 - 16020207

AN - SCOPUS:17444397718

SN - 1476-4172

VL - 6

SP - 223

EP - 226

JO - Journal of Cosmetic and Laser Therapy

JF - Journal of Cosmetic and Laser Therapy

IS - 4

ER -

Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler

Abstract

Keywords

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