Clinical features of individuals with schizotypal personality disorder with and without suicidal ideation

Leo Sher, Katelyn N. Challman, Emma C. Smith, Antonia S. New, M. Mercedes Perez-Rodriguez, Margaret M. McClure, Marianne Goodman, René S. Kahn, Erin A. Hazlett

Research output: Contribution to journalArticlepeer-review


This study compared demographic and clinical features in a sample of 384 participants: healthy controls (HC; n = 166) and individuals with schizotypal personality disorder (SPD) with (n = 50) and without (n = 168) suicidal ideation (SI) to examine specific risk factors for suicidality in SPD. Compared to the non-SI group, the SI group showed significantly greater severity of depression, aggression, impulsivity, affective lability, schizotypal features, poorer social adjustment, and had fewer social contacts. Individuals in the SI group were also more likely to have a history of a suicide attempt and comorbid borderline personality disorder in comparison to the non-SI group. Logistic regression analysis indicated that severity of depression and the number of social contacts drove the difference between the SI and non-SI groups. Compared with both SPD subgroups, the HC group was significantly less depressed, aggressive, impulsive, affectively labile, had fewer schizotypal features, was better socially adjusted, and had more social contacts. This study indicates that overall, the SI group is a more severely impaired group of individuals with SPD compared to the non-SI group. Better educating medical professionals about the diagnosis and management of SPD and its associations with suicidality is warranted.

Original languageEnglish
Article number115132
JournalPsychiatry Research
StatePublished - Apr 2023


  • Depression
  • Schizotypal personality disorder
  • Social adjustment
  • Suicidal ideation


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