Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients: A proposed diagnostic algorithm

Neil D. Parikh; Valerie Martel-Laferriere; Tatyana Kushner; Kate Childs; Marie Louise Vachon; Deepti Dronamraju; Chris Taylor; Maria Isabel Fiel; Thomas Schiano; Mark Nelson; Kosh Agarwal; Douglas T. Dieterich

doi:10.1093/infdis/jit412

Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients: A proposed diagnostic algorithm

Neil D. Parikh
, Valerie Martel-Laferriere
, Tatyana Kushner
, Kate Childs
, Marie Louise Vachon
, Deepti Dronamraju
, Chris Taylor
, Maria Isabel Fiel
, Thomas Schiano
, Mark Nelson
, Kosh Agarwal
, Douglas T. Dieterich

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.

Original language	English
Pages (from-to)	734-738
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	209
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jit412
State	Published - Mar 2014

Keywords

HIV
didanosine
esophageal variceal bleeding
liver disease
noncirrhotic portal hypertension
portal hypertension
splenomegaly
thrombocytopenia

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10.1093/infdis/jit412

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Parikh, N. D., Martel-Laferriere, V., Kushner, T., Childs, K., Vachon, M. L., Dronamraju, D., Taylor, C., Fiel, M. I., Schiano, T., Nelson, M., Agarwal, K., & Dieterich, D. T. (2014). Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients: A proposed diagnostic algorithm. Journal of Infectious Diseases, 209(5), 734-738. https://doi.org/10.1093/infdis/jit412

@article{4e0c375b283e4735b6f6aa7e6ae578ba,

title = "Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients: A proposed diagnostic algorithm",

abstract = "Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.",

keywords = "HIV, didanosine, esophageal variceal bleeding, liver disease, noncirrhotic portal hypertension, portal hypertension, splenomegaly, thrombocytopenia",

author = "Parikh, \{Neil D.\} and Valerie Martel-Laferriere and Tatyana Kushner and Kate Childs and Vachon, \{Marie Louise\} and Deepti Dronamraju and Chris Taylor and Fiel, \{Maria Isabel\} and Thomas Schiano and Mark Nelson and Kosh Agarwal and Dieterich, \{Douglas T.\}",

note = "Funding Information: Financial support. This work was supported by the 2011 AMMI Canada/Pfizer Post Residency Fellowship (to V. M. L.) and the 2012 Grant of the CHUM Foundation (to V. M. L.).",

year = "2014",

month = mar,

doi = "10.1093/infdis/jit412",

language = "English",

volume = "209",

pages = "734--738",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "5",

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Parikh, ND, Martel-Laferriere, V, Kushner, T, Childs, K, Vachon, ML, Dronamraju, D, Taylor, C, Fiel, MI, Schiano, T, Nelson, M, Agarwal, K & Dieterich, DT 2014, 'Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients: A proposed diagnostic algorithm', Journal of Infectious Diseases, vol. 209, no. 5, pp. 734-738. https://doi.org/10.1093/infdis/jit412

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T1 - Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients

T2 - A proposed diagnostic algorithm

AU - Parikh, Neil D.

AU - Martel-Laferriere, Valerie

AU - Kushner, Tatyana

AU - Childs, Kate

AU - Vachon, Marie Louise

AU - Dronamraju, Deepti

AU - Taylor, Chris

AU - Fiel, Maria Isabel

AU - Schiano, Thomas

AU - Nelson, Mark

AU - Agarwal, Kosh

AU - Dieterich, Douglas T.

N1 - Funding Information: Financial support. This work was supported by the 2011 AMMI Canada/Pfizer Post Residency Fellowship (to V. M. L.) and the 2012 Grant of the CHUM Foundation (to V. M. L.).

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N2 - Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.

AB - Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.

KW - HIV

KW - didanosine

KW - esophageal variceal bleeding

KW - liver disease

KW - noncirrhotic portal hypertension

KW - portal hypertension

KW - splenomegaly

KW - thrombocytopenia

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JO - Journal of Infectious Diseases

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IS - 5

ER -

Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients: A proposed diagnostic algorithm

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Keywords

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