TY - JOUR
T1 - Clinical factors that predict noncirrhotic portal hypertension in HIV-infected patients
T2 - A proposed diagnostic algorithm
AU - Parikh, Neil D.
AU - Martel-Laferriere, Valerie
AU - Kushner, Tatyana
AU - Childs, Kate
AU - Vachon, Marie Louise
AU - Dronamraju, Deepti
AU - Taylor, Chris
AU - Fiel, Maria Isabel
AU - Schiano, Thomas
AU - Nelson, Mark
AU - Agarwal, Kosh
AU - Dieterich, Douglas T.
N1 - Funding Information:
Financial support. This work was supported by the 2011 AMMI Canada/Pfizer Post Residency Fellowship (to V. M. L.) and the 2012 Grant of the CHUM Foundation (to V. M. L.).
PY - 2014/3
Y1 - 2014/3
N2 - Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.
AB - Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.
KW - HIV
KW - didanosine
KW - esophageal variceal bleeding
KW - liver disease
KW - noncirrhotic portal hypertension
KW - portal hypertension
KW - splenomegaly
KW - thrombocytopenia
UR - https://www.scopus.com/pages/publications/84894256645
U2 - 10.1093/infdis/jit412
DO - 10.1093/infdis/jit412
M3 - Article
C2 - 23911709
AN - SCOPUS:84894256645
SN - 0022-1899
VL - 209
SP - 734
EP - 738
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -