TY - JOUR
T1 - Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin
AU - Draelos, Zoe Diana
AU - Gunt, Hemali
AU - Zeichner, Joshua
AU - Levy, Stanley
N1 - Funding Information:
Zoe Diana Draelos, MD, received funding from Burt’s Bees to perform the research. Hemali Gunt, PhD, is an employee of Burt’s Bees. Joshua Zeichner, MD, and Stanley Levy, MD, have both received funding from Burt’s Bees.
Publisher Copyright:
© 2020 Journal of Drugs in Dermatology. All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Background: Patients with sensitive skin find topical retinoid use for anti-aging purposes challenging due to irritation. Bakuchiol, a meroterpene from the Psoralea corylifolia seed, has retinol functionality through retinol-like regulation of gene expression. Objective: This research examined the tolerability, efficacy, and barrier effects of a nature-based bakuchiol-containing cleanser and moisturizer in subjects with sensitive skin. Methods: 60 female subjects Fitzpatrick skin types I–V age 40–65 years with sensitive mild to moderate photodamaged skin were enrolled in this 4-week study. A sensitive skin panel was constructed: 1/3 eczema/atopic dermatitis, 1/3 rosacea, 1/3 cosmetic intolerance syndrome. Subjects used a nature-based cleanser and moisturizer twice daily and underwent transepidermal water loss (TEWL), corneometry, tolerability assessments, and efficacy assessments at baseline, 5–10 minutes post-application, and week 4. Results: The skin care products were well tolerated and efficacious (P<0.001) in terms of investigator assessed improvement in visual smoothness, tactile smoothness, clarity, radiance, overall appearance, and global anti-aging. Cheek corneometry measurements demonstrated a statistically significant 16% increase in skin moisture content (P<0.001). Conclusion: A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective in individuals with sensitive skin.
AB - Background: Patients with sensitive skin find topical retinoid use for anti-aging purposes challenging due to irritation. Bakuchiol, a meroterpene from the Psoralea corylifolia seed, has retinol functionality through retinol-like regulation of gene expression. Objective: This research examined the tolerability, efficacy, and barrier effects of a nature-based bakuchiol-containing cleanser and moisturizer in subjects with sensitive skin. Methods: 60 female subjects Fitzpatrick skin types I–V age 40–65 years with sensitive mild to moderate photodamaged skin were enrolled in this 4-week study. A sensitive skin panel was constructed: 1/3 eczema/atopic dermatitis, 1/3 rosacea, 1/3 cosmetic intolerance syndrome. Subjects used a nature-based cleanser and moisturizer twice daily and underwent transepidermal water loss (TEWL), corneometry, tolerability assessments, and efficacy assessments at baseline, 5–10 minutes post-application, and week 4. Results: The skin care products were well tolerated and efficacious (P<0.001) in terms of investigator assessed improvement in visual smoothness, tactile smoothness, clarity, radiance, overall appearance, and global anti-aging. Cheek corneometry measurements demonstrated a statistically significant 16% increase in skin moisture content (P<0.001). Conclusion: A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective in individuals with sensitive skin.
UR - http://www.scopus.com/inward/record.url?scp=85099008094&partnerID=8YFLogxK
U2 - 10.36849/JDD.2020.5522
DO - 10.36849/JDD.2020.5522
M3 - Article
C2 - 33346506
AN - SCOPUS:85099008094
SN - 1545-9616
VL - 19
SP - 1181
EP - 1183
JO - Journal of Drugs in Dermatology
JF - Journal of Drugs in Dermatology
IS - 12
ER -