TY - JOUR
T1 - Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin
AU - Draelos, Zoe Diana
AU - Gunt, Hemali
AU - Zeichner, Joshua
AU - Levy, Stanley
N1 - Publisher Copyright:
© 2020 Journal of Drugs in Dermatology. All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Background: Patients with sensitive skin find topical retinoid use for anti-aging purposes challenging due to irritation. Bakuchiol, a meroterpene from the Psoralea corylifolia seed, has retinol functionality through retinol-like regulation of gene expression. Objective: This research examined the tolerability, efficacy, and barrier effects of a nature-based bakuchiol-containing cleanser and moisturizer in subjects with sensitive skin. Methods: 60 female subjects Fitzpatrick skin types I–V age 40–65 years with sensitive mild to moderate photodamaged skin were enrolled in this 4-week study. A sensitive skin panel was constructed: 1/3 eczema/atopic dermatitis, 1/3 rosacea, 1/3 cosmetic intolerance syndrome. Subjects used a nature-based cleanser and moisturizer twice daily and underwent transepidermal water loss (TEWL), corneometry, tolerability assessments, and efficacy assessments at baseline, 5–10 minutes post-application, and week 4. Results: The skin care products were well tolerated and efficacious (P<0.001) in terms of investigator assessed improvement in visual smoothness, tactile smoothness, clarity, radiance, overall appearance, and global anti-aging. Cheek corneometry measurements demonstrated a statistically significant 16% increase in skin moisture content (P<0.001). Conclusion: A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective in individuals with sensitive skin.
AB - Background: Patients with sensitive skin find topical retinoid use for anti-aging purposes challenging due to irritation. Bakuchiol, a meroterpene from the Psoralea corylifolia seed, has retinol functionality through retinol-like regulation of gene expression. Objective: This research examined the tolerability, efficacy, and barrier effects of a nature-based bakuchiol-containing cleanser and moisturizer in subjects with sensitive skin. Methods: 60 female subjects Fitzpatrick skin types I–V age 40–65 years with sensitive mild to moderate photodamaged skin were enrolled in this 4-week study. A sensitive skin panel was constructed: 1/3 eczema/atopic dermatitis, 1/3 rosacea, 1/3 cosmetic intolerance syndrome. Subjects used a nature-based cleanser and moisturizer twice daily and underwent transepidermal water loss (TEWL), corneometry, tolerability assessments, and efficacy assessments at baseline, 5–10 minutes post-application, and week 4. Results: The skin care products were well tolerated and efficacious (P<0.001) in terms of investigator assessed improvement in visual smoothness, tactile smoothness, clarity, radiance, overall appearance, and global anti-aging. Cheek corneometry measurements demonstrated a statistically significant 16% increase in skin moisture content (P<0.001). Conclusion: A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective in individuals with sensitive skin.
UR - http://www.scopus.com/inward/record.url?scp=85099008094&partnerID=8YFLogxK
U2 - 10.36849/JDD.2020.5522
DO - 10.36849/JDD.2020.5522
M3 - Article
C2 - 33346506
AN - SCOPUS:85099008094
SN - 1545-9616
VL - 19
SP - 1181
EP - 1183
JO - Journal of Drugs in Dermatology
JF - Journal of Drugs in Dermatology
IS - 12
ER -