Clinical, endocrine and ultrastructural study of XY gonadal dysgenesis. A case report

Z. Blumenfeld; H. Kerner; A. Makler; A. Eshkol; J. M. Brandes

Clinical, endocrine and ultrastructural study of XY gonadal dysgenesis. A case report

Z. Blumenfeld
, H. Kerner
, A. Makler
, A. Eshkol
, J. M. Brandes

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

About 120 cases of XY gonadal dysgenesis have been reported on. We treated such a patient with bilateral gonadectomy. The gonadal tissue's capacity to respond to hormonal trophic stimulation was assessed. When the gonads were examined ultrastructurally, structures with the morphologic characteristics of stromal ovarian cells, Sertoli's cells and Leydig's cells were found. Because of the potential malignancy of the XY gonads, bilateral gonadectomy and hormonal substitution therapy are recommended for these patients. We prefer to use combined hormone replacement with sequential estrogen and progesterone rather than sequential unopposed estrogen because of the small but increased risk of endometrial hyperplasia and carcinoma after long-standing sequential therapy.

Original language	English
Pages (from-to)	211-216
Number of pages	6
Journal	Journal of Reproductive Medicine
Volume	30
Issue number	3
State	Published - 1985
Externally published	Yes

Cite this

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title = "Clinical, endocrine and ultrastructural study of XY gonadal dysgenesis. A case report",

abstract = "About 120 cases of XY gonadal dysgenesis have been reported on. We treated such a patient with bilateral gonadectomy. The gonadal tissue's capacity to respond to hormonal trophic stimulation was assessed. When the gonads were examined ultrastructurally, structures with the morphologic characteristics of stromal ovarian cells, Sertoli's cells and Leydig's cells were found. Because of the potential malignancy of the XY gonads, bilateral gonadectomy and hormonal substitution therapy are recommended for these patients. We prefer to use combined hormone replacement with sequential estrogen and progesterone rather than sequential unopposed estrogen because of the small but increased risk of endometrial hyperplasia and carcinoma after long-standing sequential therapy.",

author = "Z. Blumenfeld and H. Kerner and A. Makler and A. Eshkol and Brandes, \{J. M.\}",

year = "1985",

language = "English",

volume = "30",

pages = "211--216",

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T1 - Clinical, endocrine and ultrastructural study of XY gonadal dysgenesis. A case report

AU - Blumenfeld, Z.

AU - Kerner, H.

AU - Makler, A.

AU - Eshkol, A.

AU - Brandes, J. M.

PY - 1985

Y1 - 1985

N2 - About 120 cases of XY gonadal dysgenesis have been reported on. We treated such a patient with bilateral gonadectomy. The gonadal tissue's capacity to respond to hormonal trophic stimulation was assessed. When the gonads were examined ultrastructurally, structures with the morphologic characteristics of stromal ovarian cells, Sertoli's cells and Leydig's cells were found. Because of the potential malignancy of the XY gonads, bilateral gonadectomy and hormonal substitution therapy are recommended for these patients. We prefer to use combined hormone replacement with sequential estrogen and progesterone rather than sequential unopposed estrogen because of the small but increased risk of endometrial hyperplasia and carcinoma after long-standing sequential therapy.

AB - About 120 cases of XY gonadal dysgenesis have been reported on. We treated such a patient with bilateral gonadectomy. The gonadal tissue's capacity to respond to hormonal trophic stimulation was assessed. When the gonads were examined ultrastructurally, structures with the morphologic characteristics of stromal ovarian cells, Sertoli's cells and Leydig's cells were found. Because of the potential malignancy of the XY gonads, bilateral gonadectomy and hormonal substitution therapy are recommended for these patients. We prefer to use combined hormone replacement with sequential estrogen and progesterone rather than sequential unopposed estrogen because of the small but increased risk of endometrial hyperplasia and carcinoma after long-standing sequential therapy.

UR - https://www.scopus.com/pages/publications/0021950690

M3 - Article

C2 - 2987496

AN - SCOPUS:0021950690

SN - 0024-7758

VL - 30

SP - 211

EP - 216

JO - Journal of Reproductive Medicine

JF - Journal of Reproductive Medicine

IS - 3

ER -

Clinical, endocrine and ultrastructural study of XY gonadal dysgenesis. A case report

Abstract

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