TY - JOUR
T1 - Clinical effects of pre-adjusted edgewise orthodontic brackets
T2 - A systematic review and meta-analysis
AU - Papageorgiou, Spyridon N.
AU - Konstantinidis, Ioannis
AU - Papadopoulou, Konstantina
AU - Jäger, Andreas
AU - Bourauel, Christoph
PY - 2014/6
Y1 - 2014/6
N2 - BACKGROUND: Fixed-appliance treatment is a major part of orthodontic treatment, but clinical evidence remains scarce. OBJECTIVES: Objective of this systematic review was to investigate how the therapeutic effects and sideeffects of brackets used during the fixed-appliance orthodontic treatment are affected by their characteristics. SEARCH METHODS AND SELECTION CRITERIA: We searched MEDLINE and 18 other databases through April 2012 without restrictions for randomized controlled trials and quasi-randomized controlled trials investigating any bracket characteristic. DATA COLLECTION AND ANALYSIS: After duplicate selection and extraction procedures, risk of bias was assessed also in duplicate according to Cochrane guidelines and quality of evidence according to the Grades of Recommendation. Assessment, Development and Evaluation approach. Random-effects meta-analyses, subgroup analyses, and sensitivity analyses were performed with the corresponding 95 per cent confidence intervals (CI) and 95 per cent prediction intervals (PI). RESULTS: We included 25 trials on 1321 patients, with most comparing self-ligated (SL) and conventional brackets. Based on the meta-analyses, the duration of orthodontic treatment was on average 2.01 months longer among patients with SL brackets (95 per cent CI: 0.45 to 3.57). The 95 per cent PIs for a future trial indicated that the difference could be considerable (-1.46 to 5.47 months). Treatment characteristics, outcomes, and side-effects were clinically similar between SL and conventional brackets. For most bracket characteristics, evidence is insufficient. Some meta-analyses included trials with high risk of bias, but sensitivity analyses indicated robustness. CONCLUSIONS: Based on existing evidence, no clinical recommendation can be made regarding the bracket material or different ligation modules. For SL brackets, no conclusive benefits could be proven, while their use was associated with longer treatment durations.
AB - BACKGROUND: Fixed-appliance treatment is a major part of orthodontic treatment, but clinical evidence remains scarce. OBJECTIVES: Objective of this systematic review was to investigate how the therapeutic effects and sideeffects of brackets used during the fixed-appliance orthodontic treatment are affected by their characteristics. SEARCH METHODS AND SELECTION CRITERIA: We searched MEDLINE and 18 other databases through April 2012 without restrictions for randomized controlled trials and quasi-randomized controlled trials investigating any bracket characteristic. DATA COLLECTION AND ANALYSIS: After duplicate selection and extraction procedures, risk of bias was assessed also in duplicate according to Cochrane guidelines and quality of evidence according to the Grades of Recommendation. Assessment, Development and Evaluation approach. Random-effects meta-analyses, subgroup analyses, and sensitivity analyses were performed with the corresponding 95 per cent confidence intervals (CI) and 95 per cent prediction intervals (PI). RESULTS: We included 25 trials on 1321 patients, with most comparing self-ligated (SL) and conventional brackets. Based on the meta-analyses, the duration of orthodontic treatment was on average 2.01 months longer among patients with SL brackets (95 per cent CI: 0.45 to 3.57). The 95 per cent PIs for a future trial indicated that the difference could be considerable (-1.46 to 5.47 months). Treatment characteristics, outcomes, and side-effects were clinically similar between SL and conventional brackets. For most bracket characteristics, evidence is insufficient. Some meta-analyses included trials with high risk of bias, but sensitivity analyses indicated robustness. CONCLUSIONS: Based on existing evidence, no clinical recommendation can be made regarding the bracket material or different ligation modules. For SL brackets, no conclusive benefits could be proven, while their use was associated with longer treatment durations.
UR - http://www.scopus.com/inward/record.url?scp=84901405875&partnerID=8YFLogxK
U2 - 10.1093/ejo/cjt064
DO - 10.1093/ejo/cjt064
M3 - Review article
C2 - 24062378
AN - SCOPUS:84901405875
SN - 0141-5387
VL - 36
SP - 350
EP - 363
JO - European Journal of Orthodontics
JF - European Journal of Orthodontics
IS - 3
ER -