Clinical Effectiveness of the Cardiovascular Polypill in a Real-Life Setting in Patients With Cardiovascular Risk in Mexico: The SORS Study

Jose M. Castellano, Juan Verdejo, Salvador Ocampo, Marco Martinez Rios, Enrique Gómez-Álvarez, Gabriela Borrayo, Emilio Ruiz, Borja Ibáñez, Valentin Fuster

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: The cardiovascular disease pandemic has promoted the cardiovascular polypill as one of the most scalable public health strategies to improve cardiovascular risk by increasing accessibility and adherence to treatments. Data from randomized clinical trials has shown that the polypill strategy significantly improves adherence as well as risk factor control (cholesterol and blood pressure), however, to date, no information from phase IV registries has been available. Methods: We conducted a multicentre, observational and prospective registry of a polypill-based treatment strategy. A total of 1193 patients in Mexico were included. Patient demographics, clinical history, blood pressure, analysis of blood lipids and the Framingham risk score were measured at baseline and after 12 months of treatment with the CNIC-Ferrer polypill. Results: At one year with the polypill, systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels changed from mean 146.9 mmHg to 128 mmHg (p < 0.001), and from 89.1 mmHg to 80.4 mmHg (p < 0.001) respectively. LDLc levels were significantly reduced 132.5–107.6 mg/dL (p < 0.001). The 10 year Framingham cardiovascular disease risk was also reduced in the high-risk group (33.7 + 22.0 vs. 21.2 + 14.8; p < 0.001) and in the intermediate risk group (23.7 + 14.8 vs. 12.7 + 11.4; p < 0.001). Conclusions: To our knowledge, the results of the current study constitute the first real life data on the impact of a polypill therapy on cardiovascular risk factor control. The results show major improvements on the primary outcome, above and beyond those presented previously in the setting of randomized clinical trials.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalArchives of Medical Research
Issue number1
StatePublished - Jan 2019


  • Adherence
  • Cardiovascular polypill
  • Cardiovascular risk factors
  • Global cardiovascular risk
  • High-risk primary prevention
  • Secondary prevention


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