Clinical decision rules and D-dimer in venous thromboembolism: Current controversies and future research priorities

Marc A. Rodger, Gregoire Le Gal, Philip Wells, Trevor Baglin, Drahomir Aujesky, Marc Righini, Gualtiero Palareti, Menno Huisman, Guy Meyer

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Venous thromboembolism (VTE) is a potentially lethal clinical condition that is suspected in patients with common clinical complaints, in many and varied, clinical care settings. Once VTE is diagnosed, optimal therapeutic management (thrombolysis, IVC filters, type and duration of anticoagulants) and ideal therapeutic management settings (outpatient, critical care) are also controversial. Clinical prediction tools, including clinical decision rules and D-Dimer, have been developed, and some validated, to assist clinical decision making along the diagnostic and therapeutic management paths for VTE. Despite these developments, practice variation is high and there remain many controversies in the use of the clinical prediction tools. In this narrative review, we highlight challenges and controversies in VTE diagnostic and therapeutic management with a focus on clinical decision rules and D-Dimer.

Original languageEnglish
Pages (from-to)763-768
Number of pages6
JournalThrombosis Research
Volume134
Issue number4
DOIs
StatePublished - 1 Oct 2014
Externally publishedYes

Keywords

  • Clinical Decision Rules
  • D-dimer
  • Diagnosis
  • Prognosis
  • Treatment
  • Venous Thromboembolism

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