Clinical care and therapeutic trials in PLS

Mary Kay Floeter, Deborah Warden, Dale Lange, James Wymer, Sabrina Paganoni, Hiroshi Mitsumoto

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Primary lateral sclerosis (PLS) is an extremely rare central nervous system degenerative disorder characterized by slowly progressive upper motor neuron loss leading to severe limb and bulbar dysfunction and disability. Although not necessarily life-shortening, PLS disease burden is substantial and improved symptomatic treatments are a major unmet need, especially for the often refractory spasticity that is a core feature of the syndrome. In Section 1, we describe clinical care needs and emphasize a highly personalized approach that can be best attained through multidisciplinary management. In Section 2, we describe progress in clinical trials in PLS that includes advances in symptomatic treatment, disease-modifying therapy, and emerging innovative trials.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Issue numberS1
StatePublished - 2020
Externally publishedYes


  • Care and management
  • Clinical trials
  • PLS
  • Review
  • Supplement


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