Clinical applications of microarrays in cancer

Marilyn M. Li, Ankita Patel, Xiaofeng Hu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Genetic alterations are important biological markers for cancer diagnosis and prognosis, disease classification, risk stratification, and treatment selection. Microarray-based cytogenetic technology is a superb new method for evaluating cancer genomes. This technology offers high-resolution, highly accurate targeted and whole genome evaluation of tumor tissues independent of cell division. Application of microarray-based technology in cancer research has generated a wealth of useful information about copy number variations (CNVs) and their implications in cancer classification, disease progression, therapy response, and patient outcome. There is an increasing interest in the genetic diagnostic community in applying this new technology to cancer diagnosis in CLIA certified laboratories. We anticipate that microarray-based cancer cytogenetics will soon become one of the major diagnostic means for cancer genome analysis, especially for solid tumors and hematological malignancies with prominent genomic imbalances.

Original languageEnglish
Title of host publicationModern Clinical Molecular Techniques
PublisherSpringer New York
Pages307-322
Number of pages16
ISBN (Electronic)9781461421702
ISBN (Print)1461421691, 9781461421696
DOIs
StatePublished - 1 Jul 2012
Externally publishedYes

Keywords

  • Aberration Detection Method 1 algorithm (ADM-1)
  • Amplification
  • CMA (chromosome microarray analysis)
  • CNV (copy number variation)
  • Cancer microarray
  • Deletion
  • Duplication
  • LOH (loss of heterozygosity)
  • SNP (single nucleotide polymorphism)
  • aCGH (microarray-based comparative genomic hybridization)

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