Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

Michael Iv; Nicholas Telischak; Dan Feng; Samantha J. Holdsworth; Kristen W. Yeom; Heike E. Daldrup-Link

doi:10.2217/nnm.14.203

Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

Michael Iv
, Nicholas Telischak
, Dan Feng
, Samantha J. Holdsworth
, Kristen W. Yeom
, Heike E. Daldrup-Link

Research output: Contribution to journal › Review article › peer-review

120 Scopus citations

Abstract

Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.

Original language	English
Pages (from-to)	993-1008
Number of pages	16
Journal	Nanomedicine
Volume	10
Issue number	6
DOIs	https://doi.org/10.2217/nnm.14.203
State	Published - 1 Mar 2015
Externally published	Yes

Keywords

MRI
brain tumor
ferucarbotran
ferumoxtran
ferumoxytol
macrophage
ultrasmall superparamagnetic iron oxide nanoparticles

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10.2217/nnm.14.203

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title = "Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors",

abstract = "Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.",

keywords = "MRI, brain tumor, ferucarbotran, ferumoxtran, ferumoxytol, macrophage, ultrasmall superparamagnetic iron oxide nanoparticles",

author = "Michael Iv and Nicholas Telischak and Dan Feng and Holdsworth, \{Samantha J.\} and Yeom, \{Kristen W.\} and Daldrup-Link, \{Heike E.\}",

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doi = "10.2217/nnm.14.203",

language = "English",

volume = "10",

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T1 - Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

AU - Iv, Michael

AU - Telischak, Nicholas

AU - Feng, Dan

AU - Holdsworth, Samantha J.

AU - Yeom, Kristen W.

AU - Daldrup-Link, Heike E.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.

AB - Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.

KW - MRI

KW - brain tumor

KW - ferucarbotran

KW - ferumoxtran

KW - ferumoxytol

KW - macrophage

KW - ultrasmall superparamagnetic iron oxide nanoparticles

UR - https://www.scopus.com/pages/publications/84928167324

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DO - 10.2217/nnm.14.203

M3 - Review article

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AN - SCOPUS:84928167324

SN - 1743-5889

VL - 10

SP - 993

EP - 1008

JO - Nanomedicine

JF - Nanomedicine

IS - 6

ER -

Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

Abstract

Keywords

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