TY - JOUR
T1 - Clinical Applications for Biomarkers of Acute and Chronic Graft-versus-Host Disease
AU - Levine, John E.
AU - Paczesny, Sophie
AU - Sarantopoulos, Stefanie
N1 - Funding Information:
Financial disclosure: This work was supported by NIH grants CA039542 and HL101102 . SP is an Amy Strelzer Manasevit Scholar.
PY - 2012/1
Y1 - 2012/1
N2 - Acute and chronic graft-versus-host disease (aGVHD, cGVHD) are serious complications of allogeneic hematopoietic cell transplantation. The complex pathophysiology of these disease processes is associated with immune system activation, the release of cytokines and chemokines, and alterations in cell populations. The blood levels of specific protein and cellular levels in patients with GVHD have correlated with the development, diagnosis, and prognosis of GVHD. Here, we review the most promising biomarkers for aGVHD and cGVHD with clinical relevance. The utility of GVHD biomarkers in clinical care of allogeneic hematopoietic cell transplantation recipients needs to be proven through clinical trials, and potential approaches to trial design are discussed.
AB - Acute and chronic graft-versus-host disease (aGVHD, cGVHD) are serious complications of allogeneic hematopoietic cell transplantation. The complex pathophysiology of these disease processes is associated with immune system activation, the release of cytokines and chemokines, and alterations in cell populations. The blood levels of specific protein and cellular levels in patients with GVHD have correlated with the development, diagnosis, and prognosis of GVHD. Here, we review the most promising biomarkers for aGVHD and cGVHD with clinical relevance. The utility of GVHD biomarkers in clinical care of allogeneic hematopoietic cell transplantation recipients needs to be proven through clinical trials, and potential approaches to trial design are discussed.
KW - Acute GVHD
KW - Allogeneic hematopoietic cell transplantation
KW - Biomarkers
KW - Chronic GVHD
UR - https://www.scopus.com/pages/publications/84855376470
U2 - 10.1016/j.bbmt.2011.10.019
DO - 10.1016/j.bbmt.2011.10.019
M3 - Article
C2 - 22226094
AN - SCOPUS:84855376470
SN - 1083-8791
VL - 18
SP - S116-S124
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 1 SUPPL.
ER -