Clinical and positron emission tomography of Parkinson's disease caused by LRRK2

Dena G. Hernandez, Coro Paisán-Ruíz, Aideen McInerney-Leo, Shushant Jain, Andreas Meyer-Lindenberg, E. Whitney Evans, Karen F. Berman, Janel Johnson, Georg Auburger, Alejandro A. Schäffer, Grisel J. Lopez, Robert L. Nussbaum, Andrew B. Singleton

Research output: Contribution to journalArticlepeer-review

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Abstract

We have recently identified mutations in a gene leucine-rich repeat kinase-2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of patients, including 6-18F-fluoro-L-dopa positron emission tomography and discuss the potential implications of this mutation, which alters a conserved residue in a domain required for kinase activation.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalAnnals of Neurology
Volume57
Issue number3
DOIs
StatePublished - Mar 2005
Externally publishedYes

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