Clinical and immunological evaluation of cat-allergic asthmatics living with or without a cat

Erik R. Wambre, Mary Farrington, Veronique Bajzik, Hannah A. DeBerg, Marcella Ruddy, Michelle DeVeaux, Pretty Meier, David Robinson, Matt Cantor, Chengrui Huang, Jamie M. Orengo, Claire Q. Wang, Allen Radin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Characterising the clinical and immunological impact of daily cat exposure in cat-allergic subjects with asthma who live with cats (WC) and those who do not (WoC) may provide understanding of the drivers of the allergic response. Methods: Clinical and immunological characteristics (skin prick test, spirometry, symptom assessments, immunological markers) were compared between asthmatic subjects WC (n = 10) and WoC (n = 9). Results: WC subjects had greater use of long-acting beta agonists (p <.05) and high-potency corticosteroids. No differences were observed in lung function, nasal and ocular symptoms, or asthma control between the groups. Cat dander- and Fel d 1-specific IgG4 concentrations were higher in WC than WoC subjects (both p <.05). Total IgE and cat dander-, Fel d 1- and Fel d 7-specific IgE concentrations were similar, but Fel d 4-sIgE was higher in WC subjects (p <.05) versus WoC. Basophil sensitivity to cat dander extract and Fel d 1 was lower in WC versus WoC subjects (p <.05) and correlated with higher IgG4 concentrations (r = 0.63; p =.009). Fel d 1-specific CD4+ T-cell responses polarised toward Th2A responses in WC versus WoC subjects; Fel d 1-specific IgE correlated with surface expression of CRTH2 and CD200R (both p ≤.05). Conclusion: Immunological differences observed in WC versus WoC did not reflect clinical tolerance with natural cat exposure. The ability to live with a cat despite allergy could be driven by higher preventative medication use. This study may support design of novel therapeutics for allergy management.

Original languageEnglish
Pages (from-to)1624-1633
Number of pages10
JournalClinical and Experimental Allergy
Issue number12
StatePublished - Dec 2021
Externally publishedYes


  • Fel d 1
  • Th2A cells
  • basophil activation
  • cat allergy
  • immunoglobulins


Dive into the research topics of 'Clinical and immunological evaluation of cat-allergic asthmatics living with or without a cat'. Together they form a unique fingerprint.

Cite this