Clinical and genetic associations of radiographic sacroiliitis and its different patterns in psoriatic arthritis

Muhammad Haroon, Robert Winchester, Jon T. Giles, Eric Heffernan, Oliver FitzGerald

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Objective We aimed to 1) identify clinical and genetic associations of sacroiliitis (SI) in patients with psoriatic arthritis (PsA), and 2) describe the different radiographic patterns of SI in PsA and their clinical and genetic associations. Methods 283 PsA patients, fulfilling CASPAR criteria, underwent detailed skin and rheumatologic assessments. In addition, HLA-B*27 and B*080101 status was recorded, which have been shown as the key genetic markers of radiographic SI in PsA. Grade 2 Unilateral or bilateral radiographic changes of SI were required for inclusion and involvement was further defined as asymmetrical or symmetrical. Results 70 patients (25%) had radiographic SI; all either with a present or past history of backache. Regression analysis demonstrated a significant association of SI with peripheral joint erosions (p=0.043), PASI maximum (p=0.041), younger age of PsA onset (p= < 0.001), presence of HLA-B*0801 (p=0.002) and only marginal significance with HLA-B*2705 (p=0.059). Asymmetrical SI was noted in 51 patients (73%). In striking contrast to those patients with symmetrical SI, patients with asymmetrical SI were more likely to be female (p=0.04), have a trend towards more severe nail disease (p=0.08) and peripheral joint erosions (p=0.08), more osteolysis (p=0.01), more HLA-B*0801 positivity (p=0.001) and much less HLA-B*270502 positivity (p= < 0.001). Conclusion PsA developing at a younger age, severe skin disease, peripheral joint erosions, and HLA-B*0801 are significantly associated with SI, and there was only a marginal trend towards significance for HLA-B*2705. HLA-B*27 positive Axial-PsA patients resemble AS, while HLA-B*0801 positive Axial-PsA patients have asymmetrical and/or unilateral SI, which are typical of PsA.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalClinical and Experimental Rheumatology
Volume35
Issue number2
StatePublished - 2017
Externally publishedYes

Keywords

  • HLA alleles
  • Phenotype
  • Psoriatic arthritis
  • Susceptibility

Fingerprint

Dive into the research topics of 'Clinical and genetic associations of radiographic sacroiliitis and its different patterns in psoriatic arthritis'. Together they form a unique fingerprint.

Cite this