Clenbuterol Increases Lean Muscle Mass but Not Endurance in Patients With Chronic Heart Failure

Gayathri Kamalakkannan, Christopher M. Petrilli, Isaac George, John LaManca, Brooke T. McLaughlin, Elizabeth Shane, Donna M. Mancini, Simon Maybaum

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Clenbuterol, a β2-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery in patients with left ventricular assist devices. In a small, randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity in patients with chronic heart failure. Clenbuterol was well tolerated and led to a significant increase in both lean mass and the lean/fat ratio. Maximal strength increased significantly with both clenbuterol (27%) and placebo (14%); however, endurance and exercise duration decreased after clenbuterol. Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach.

Original languageEnglish
Pages (from-to)457-461
Number of pages5
JournalJournal of Heart and Lung Transplantation
Volume27
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Dive into the research topics of 'Clenbuterol Increases Lean Muscle Mass but Not Endurance in Patients With Chronic Heart Failure'. Together they form a unique fingerprint.

Cite this