Clearing the air: A review of the effects of air pollution on dialysis outcomes

Purpose of reviewAn evolving body of literature indicates exposure to air pollutants is associated with adverse health outcomes in dialysis patients. As the prevalence of kidney disease increases, understanding the role of environmental agents on the health of dialysis patients is critical to reducing global morbidity and mortality.Recent findingsWe identified 16 publications that investigated associations between pollutants including particulate matter (PM^2.5and PM¹⁰), carbon monoxide (CO), nitrogen dioxide (NO²), sulfur dioxide (SO²), and ozone (O³) and health outcomes among dialysis patients. Eight studies examined the effects of particulate matter (PM) and four studies examined the effects CO exposure on dialysis patients. Exposure to PM was consistently associated with outcomes including all-cause mortality and a smaller body of literature suggested relationships with subclinical outcomes. Exposure to CO was associated with all-cause mortality, generalized inflammation, and uremic pruritus. An additional four studies examined multiple pollutant exposures including NO², SO², and O³and reported associations with all-cause mortality in dialysis patients.SummaryThis review emphasized the nascent literature that demonstrates consistent relationships between air pollutant exposure and adverse outcomes among dialysis patients. Further research is needed to assess the impact of air pollutants, including how co-exposures will impact dialysis patient health.