Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy

Louise Kelly; Christopher Brown; Daniel Michalik; Cheryl A. Hawkes; Roxana Aldea; Nivedita Agarwal; Rami Salib; Aiman Alzetani; Douglas W. Ethell; Scott E. Counts; Mony de Leon; Silvia Fossati; Maya Koronyo-Hamaoui; Fabrizio Piazza; Steven A. Rich; Frank J. Wolters; Heather Snyder; Ozama Ismail; Fanny Elahi; Steven T. Proulx; Ajay Verma; Hilary Wunderlich; Mareike Haack; Jean Cosme Dodart; Norman Mazer; Roxana O. Carare

doi:10.1002/alz.13512

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy

Louise Kelly, Christopher Brown, Daniel Michalik, Cheryl A. Hawkes, Roxana Aldea, Nivedita Agarwal, Rami Salib, Aiman Alzetani, Douglas W. Ethell, Scott E. Counts, Mony de Leon, Silvia Fossati, Maya Koronyo-Hamaoui, Fabrizio Piazza, Steven A. Rich, Frank J. Wolters, Heather Snyder, Ozama Ismail, Fanny Elahi, Steven T. ProulxAjay Verma, Hilary Wunderlich, Mareike Haack, Jean Cosme Dodart, Norman Mazer, Roxana O. Carare

Neurology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid-related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA-related inflammation (CAA-ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.

Original language	English
Pages (from-to)	1421-1435
Number of pages	15
Journal	Alzheimer's and Dementia
Volume	20
Issue number	2
DOIs	https://doi.org/10.1002/alz.13512
State	Published - Feb 2024

Keywords

ARIA
IPAD
ISTAART
amyloid
cerebrospinal fluid
clearance
interstitial fluid

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Kelly, L., Brown, C., Michalik, D., Hawkes, C. A., Aldea, R., Agarwal, N., Salib, R., Alzetani, A., Ethell, D. W., Counts, S. E., de Leon, M., Fossati, S., Koronyo-Hamaoui, M., Piazza, F., Rich, S. A., Wolters, F. J., Snyder, H., Ismail, O., Elahi, F., ... Carare, R. O. (2024). Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's and Dementia, 20(2), 1421-1435. https://doi.org/10.1002/alz.13512

Kelly, Louise ; Brown, Christopher ; Michalik, Daniel et al. / Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease : Opportunities for therapy. In: Alzheimer's and Dementia. 2024 ; Vol. 20, No. 2. pp. 1421-1435.

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title = "Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy",

abstract = "This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid-related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA-related inflammation (CAA-ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.",

keywords = "ARIA, IPAD, ISTAART, amyloid, cerebrospinal fluid, clearance, interstitial fluid",

author = "Louise Kelly and Christopher Brown and Daniel Michalik and Hawkes, {Cheryl A.} and Roxana Aldea and Nivedita Agarwal and Rami Salib and Aiman Alzetani and Ethell, {Douglas W.} and Counts, {Scott E.} and {de Leon}, Mony and Silvia Fossati and Maya Koronyo-Hamaoui and Fabrizio Piazza and Rich, {Steven A.} and Wolters, {Frank J.} and Heather Snyder and Ozama Ismail and Fanny Elahi and Proulx, {Steven T.} and Ajay Verma and Hilary Wunderlich and Mareike Haack and Dodart, {Jean Cosme} and Norman Mazer and Carare, {Roxana O.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2024",

month = feb,

doi = "10.1002/alz.13512",

language = "English",

volume = "20",

pages = "1421--1435",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

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Kelly, L, Brown, C, Michalik, D, Hawkes, CA, Aldea, R, Agarwal, N, Salib, R, Alzetani, A, Ethell, DW, Counts, SE, de Leon, M, Fossati, S, Koronyo-Hamaoui, M, Piazza, F, Rich, SA, Wolters, FJ, Snyder, H, Ismail, O, Elahi, F, Proulx, ST, Verma, A, Wunderlich, H, Haack, M, Dodart, JC, Mazer, N & Carare, RO 2024, 'Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy', Alzheimer's and Dementia, vol. 20, no. 2, pp. 1421-1435. https://doi.org/10.1002/alz.13512

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. / Kelly, Louise; Brown, Christopher; Michalik, Daniel et al.
In: Alzheimer's and Dementia, Vol. 20, No. 2, 02.2024, p. 1421-1435.

Research output: Contribution to journal › Review article › peer-review

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T2 - Opportunities for therapy

AU - Kelly, Louise

AU - Brown, Christopher

AU - Michalik, Daniel

AU - Hawkes, Cheryl A.

AU - Aldea, Roxana

AU - Agarwal, Nivedita

AU - Salib, Rami

AU - Alzetani, Aiman

AU - Ethell, Douglas W.

AU - Counts, Scott E.

AU - de Leon, Mony

AU - Fossati, Silvia

AU - Koronyo-Hamaoui, Maya

AU - Piazza, Fabrizio

AU - Rich, Steven A.

AU - Wolters, Frank J.

AU - Snyder, Heather

AU - Ismail, Ozama

AU - Elahi, Fanny

AU - Proulx, Steven T.

AU - Verma, Ajay

AU - Wunderlich, Hilary

AU - Haack, Mareike

AU - Dodart, Jean Cosme

AU - Mazer, Norman

AU - Carare, Roxana O.

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N2 - This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid-related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA-related inflammation (CAA-ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.

AB - This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid-related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA-related inflammation (CAA-ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.

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KW - IPAD

KW - ISTAART

KW - amyloid

KW - cerebrospinal fluid

KW - clearance

KW - interstitial fluid

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U2 - 10.1002/alz.13512

DO - 10.1002/alz.13512

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Kelly L, Brown C, Michalik D, Hawkes CA, Aldea R, Agarwal N et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's and Dementia. 2024 Feb;20(2):1421-1435. doi: 10.1002/alz.13512