CLA+ memory T cells in atopic dermatitis: CLA+ T cells and atopic dermatitis

Daniel Lozano-Ojalvo, Emma Guttman-Yassky

Research output: Contribution to journalReview articlepeer-review


Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
StateAccepted/In press - 2023


  • CLA T cells
  • atopic dermatitis
  • biomarker
  • skin-homing
  • translational


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