Circulation of mumps virus genotypes in Spain from 1996 to 2007

J. E. Echevarría, A. Castellanos, J. C. Sanz, C. Pérez, G. Palacios, M. V. De Martínez Aragón, I. Peña Rey, M. Mosquera, F. De Ory, E. Royuela

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27 Scopus citations

Abstract

Although the WHO recommends the use of genotyping as a tool for epidemiological surveillance for mumps, limited data on mumps virus (MV) genotype circulation that may be used to trace the patterns of virus spread are available. We describe the first complete series of data from Spain. The small hydrophobic region was sequenced from 237 MV-positive samples from several regions of Spain collected between 1996 and 2007. Six different genotypes were identified: A, C, D (D1), G (G1, G2), H (H1, H2), and J. Genotype Hl was predominant during the epidemic that occurred from 1999 to 2003 but was replaced by genotype Gl as the dominant genotype in the epidemic that occurred from 2005 to 2007. The same genotype G1 strain caused concomitant outbreaks in different parts of the world (the United States, Canada, and the United Kingdom). The remaining genotypes (genotypes A, C, D, and J) appeared in sporadic cases or small limited outbreaks. This pattern of circulation seems to reflect continuous viral circulation at the national level, despite the high rates of vaccine coverage.

Original languageEnglish
Pages (from-to)1245-1254
Number of pages10
JournalJournal of Clinical Microbiology
Volume48
Issue number4
DOIs
StatePublished - 1 Apr 2010
Externally publishedYes

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