TY - JOUR
T1 - Circulating Lp-PLA2 is associated with high valvuloarterial impedance and low arterial compliance in patients with aortic valve bioprostheses
AU - Mahmut, Ablajan
AU - Mahjoub, Haïfa
AU - Boulanger, Marie Chloé
AU - Dahou, Abdellaziz
AU - Bouchareb, Rihab
AU - Capoulade, Romain
AU - Arsenault, Benoît J.
AU - Larose, Eric
AU - Bossé, Yohan
AU - Pibarot, Philippe
AU - Mathieu, Patrick
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background: We previously reported that plasma Lp-PLA2 was associated with aortic valve disease progression and degeneration of bioprostheses. Low systemic arterial compliance and high valvuloarterial impedance (Zva) are predictors of poor survival in patients with aortic valve disease. However, the prevalence of high Zva after AVR is largely unknown and whether Lp-PLA2 could predict Zva has not been documented. We investigated the relationships between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity and valvuloarterial impedance (Zva), an index of global LV hemodynamic load, in patients that underwent aortic valve replacement (AVR). Methods: A total of 195 patients with aortic bioprostheses underwent echocardiographic assessment of the prosthetic aortic valve function 8 ± 3.4 years after AVR. Lp-PLA2 mass and activity were measured. Results: In this group of patients, the mean Zva was elevated (5.73±1.21 mm Hg·ml-1·m2). In univariate analyses, Lp-PLA2 mass (p=0.003) and Lp-PLA2 activity (p=0.046) were associated with Zva. After adjustment for covariates including age, gender, clinical risk factors, anti-hypertensive medications, body mass index and prosthesis size, Lp-PLA2 mass was associated with high Zva (≥4.5 mm Hg·ml-1·m2) (OR: 1.29, 95%CI: 1.10-1.53; p=0.005) and was inversely related with the systemic arterial compliance (β=-0.01, SEM=0.003; p=0.003). Conclusions: An increased Zva, an index of excessive hemodynamic load, was highly prevalent 8-year post-AVR and was independently related to circulating Lp-PLA2.
AB - Background: We previously reported that plasma Lp-PLA2 was associated with aortic valve disease progression and degeneration of bioprostheses. Low systemic arterial compliance and high valvuloarterial impedance (Zva) are predictors of poor survival in patients with aortic valve disease. However, the prevalence of high Zva after AVR is largely unknown and whether Lp-PLA2 could predict Zva has not been documented. We investigated the relationships between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity and valvuloarterial impedance (Zva), an index of global LV hemodynamic load, in patients that underwent aortic valve replacement (AVR). Methods: A total of 195 patients with aortic bioprostheses underwent echocardiographic assessment of the prosthetic aortic valve function 8 ± 3.4 years after AVR. Lp-PLA2 mass and activity were measured. Results: In this group of patients, the mean Zva was elevated (5.73±1.21 mm Hg·ml-1·m2). In univariate analyses, Lp-PLA2 mass (p=0.003) and Lp-PLA2 activity (p=0.046) were associated with Zva. After adjustment for covariates including age, gender, clinical risk factors, anti-hypertensive medications, body mass index and prosthesis size, Lp-PLA2 mass was associated with high Zva (≥4.5 mm Hg·ml-1·m2) (OR: 1.29, 95%CI: 1.10-1.53; p=0.005) and was inversely related with the systemic arterial compliance (β=-0.01, SEM=0.003; p=0.003). Conclusions: An increased Zva, an index of excessive hemodynamic load, was highly prevalent 8-year post-AVR and was independently related to circulating Lp-PLA2.
KW - Arterial compliance
KW - Bioprosthesis
KW - Calcific aortic valve disease
KW - Lipoprotein-associated phospholipase A2
KW - Lp-PLA2
KW - Valvuloarterial impedance
UR - http://www.scopus.com/inward/record.url?scp=84955504338&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2016.01.014
DO - 10.1016/j.cca.2016.01.014
M3 - Article
C2 - 26797670
AN - SCOPUS:84955504338
SN - 0009-8981
VL - 455
SP - 20
EP - 25
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -