Circling back to PTEN: Fumarate inhibits canonical tumor suppressor

Sally E. Claridge; Benjamin D. Hopkins

doi:10.1016/j.molcel.2022.03.013

Circling back to PTEN: Fumarate inhibits canonical tumor suppressor

Sally E. Claridge
, Benjamin D. Hopkins

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis.

Original language	English
Pages (from-to)	1244-1245
Number of pages	2
Journal	Molecular Cell
Volume	82
Issue number	7
DOIs	https://doi.org/10.1016/j.molcel.2022.03.013
State	Published - 7 Apr 2022

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10.1016/j.molcel.2022.03.013

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title = "Circling back to PTEN: Fumarate inhibits canonical tumor suppressor",

abstract = "Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis.",

author = "Claridge, \{Sally E.\} and Hopkins, \{Benjamin D.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = apr,

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doi = "10.1016/j.molcel.2022.03.013",

language = "English",

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T1 - Circling back to PTEN

T2 - Fumarate inhibits canonical tumor suppressor

AU - Claridge, Sally E.

AU - Hopkins, Benjamin D.

PY - 2022/4/7

Y1 - 2022/4/7

N2 - Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis.

AB - Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis.

UR - https://www.scopus.com/pages/publications/85127314107

U2 - 10.1016/j.molcel.2022.03.013

DO - 10.1016/j.molcel.2022.03.013

M3 - Comment/debate

C2 - 35395197

AN - SCOPUS:85127314107

SN - 1097-2765

VL - 82

SP - 1244

EP - 1245

JO - Molecular Cell

JF - Molecular Cell

IS - 7

ER -

Circling back to PTEN: Fumarate inhibits canonical tumor suppressor

Abstract

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