TY - JOUR
T1 - Circadian Rhythm Disruption as a Contributor to Racial Disparities in Prostate Cancer
AU - Dasari, Sonali S.
AU - Archer, Maddison
AU - Mohamed, Nihal E.
AU - Tewari, Ashutosh K.
AU - Figueiro, Mariana G.
AU - Kyprianou, Natasha
N1 - Funding Information:
This work was supported by the following funding: Grant # R01 CA232574/National Institutes of Health/NCI (NK); Grant #R01OH01668/NIH/NIOSH (MGF); the Deane Prostate Health and The Arthur M. Blank Family Foundation (AKT); Department of Defense W81XWH-17-1-0590 #PC160194 and the National Institute of Nursing Research (1R21 NR0165)18-01A1 (NEM).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - In the United States, African American (AA) men have a 2.4 times higher mortality rate due to prostate cancer than White men. The multifactorial causes of the racial disparities in prostate cancer involve various social determinants of health, socioeconomic status, and access to healthcare. However, emerging evidence also suggests that circadian rhythm disruption (CRD) contributes to prostate cancer, and AA men may be more susceptible to developing CRDs. Circadian rhythms play a significant role in metabolism, hormone secretion, and sleep/wake cycles. Disruption in these circadian rhythms can be caused by airplane travel/jetlag, night shift work, exposure to light, and neighborhood noise levels, which can contribute to sleep disorders and chronic conditions such as obesity, diabetes, cardiovascular disease, and depression. The drivers of the racial disparities in CRD include night shift work, racial discrimination, elevated stress, and residing in poor neighborhoods characterized by high noise pollution. Given the increased vulnerability of AA men to CRDs, and the role that CRDs play in prostate cancer, elucidating the clock-related prostate cancer pathways and their behavior and environmental covariates may be critical to better understanding and reducing the racial disparities in prostate cancer.
AB - In the United States, African American (AA) men have a 2.4 times higher mortality rate due to prostate cancer than White men. The multifactorial causes of the racial disparities in prostate cancer involve various social determinants of health, socioeconomic status, and access to healthcare. However, emerging evidence also suggests that circadian rhythm disruption (CRD) contributes to prostate cancer, and AA men may be more susceptible to developing CRDs. Circadian rhythms play a significant role in metabolism, hormone secretion, and sleep/wake cycles. Disruption in these circadian rhythms can be caused by airplane travel/jetlag, night shift work, exposure to light, and neighborhood noise levels, which can contribute to sleep disorders and chronic conditions such as obesity, diabetes, cardiovascular disease, and depression. The drivers of the racial disparities in CRD include night shift work, racial discrimination, elevated stress, and residing in poor neighborhoods characterized by high noise pollution. Given the increased vulnerability of AA men to CRDs, and the role that CRDs play in prostate cancer, elucidating the clock-related prostate cancer pathways and their behavior and environmental covariates may be critical to better understanding and reducing the racial disparities in prostate cancer.
KW - artificial light at night
KW - circadian genes
KW - jet lag
KW - melatonin
KW - night shift work
KW - obesity
KW - prostate cancer
KW - racial disparities
KW - stress
KW - treatment resistance
UR - http://www.scopus.com/inward/record.url?scp=85140611851&partnerID=8YFLogxK
U2 - 10.3390/cancers14205116
DO - 10.3390/cancers14205116
M3 - Review article
AN - SCOPUS:85140611851
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 20
M1 - 5116
ER -