Circadian disruption: Comparing humans with mice

Leora C. Radetsky, Mark S. Rea, Andrew Bierman, Mariana G. Figueiro

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Disruption of the 24-h light-dark cycle has been implicated as an endocrine disruptor and linked to increased morbidity and mortality in animal studies. Previously reported measurements of circadian disruption in day-shift and rotating-shift nurses were compared with new mouse data where the light-dark patterns simulated shiftwork. Phasor magnitudes, a measure of circadian entrainment, were shown to be similar for humans and for mice when exposed to similar patterns of light and dark. Phasor analyses may be a useful method for quantitatively bridging ecological measurements of circadian disruption in human with parametric studies of health outcomes in a mouse model.

Original languageEnglish
Pages (from-to)1066-1071
Number of pages6
JournalChronobiology International
Issue number8
StatePublished - Oct 2013
Externally publishedYes


  • Animal models
  • Circadian disruption
  • Ecological measurements
  • Shiftwork


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