Circadian disruption: Comparing humans with mice

Leora C. Radetsky; Mark S. Rea; Andrew Bierman; Mariana G. Figueiro

doi:10.3109/07420528.2013.797428

Circadian disruption: Comparing humans with mice

Leora C. Radetsky, Mark S. Rea, Andrew Bierman, Mariana G. Figueiro

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Disruption of the 24-h light-dark cycle has been implicated as an endocrine disruptor and linked to increased morbidity and mortality in animal studies. Previously reported measurements of circadian disruption in day-shift and rotating-shift nurses were compared with new mouse data where the light-dark patterns simulated shiftwork. Phasor magnitudes, a measure of circadian entrainment, were shown to be similar for humans and for mice when exposed to similar patterns of light and dark. Phasor analyses may be a useful method for quantitatively bridging ecological measurements of circadian disruption in human with parametric studies of health outcomes in a mouse model.

Original language	English
Pages (from-to)	1066-1071
Number of pages	6
Journal	Chronobiology International
Volume	30
Issue number	8
DOIs	https://doi.org/10.3109/07420528.2013.797428
State	Published - Oct 2013
Externally published	Yes

Keywords

Animal models
Circadian disruption
Ecological measurements
Shiftwork

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10.3109/07420528.2013.797428

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abstract = "Disruption of the 24-h light-dark cycle has been implicated as an endocrine disruptor and linked to increased morbidity and mortality in animal studies. Previously reported measurements of circadian disruption in day-shift and rotating-shift nurses were compared with new mouse data where the light-dark patterns simulated shiftwork. Phasor magnitudes, a measure of circadian entrainment, were shown to be similar for humans and for mice when exposed to similar patterns of light and dark. Phasor analyses may be a useful method for quantitatively bridging ecological measurements of circadian disruption in human with parametric studies of health outcomes in a mouse model.",

keywords = "Animal models, Circadian disruption, Ecological measurements, Shiftwork",

author = "Radetsky, {Leora C.} and Rea, {Mark S.} and Andrew Bierman and Figueiro, {Mariana G.}",

note = "Funding Information: The study was funded by the Office of Naval Research (grant no. N00014-11-1-0572) and the National Cancer Institute (grant no. R03CA142097). Philips Color Kinetics is acknowledged for providing the DMX system (ColorPlay 3). The sponsors and manufacturer did not have any role in the experimental design, data collection, data analyses, or manuscript writing.",

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AU - Bierman, Andrew

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Circadian disruption: Comparing humans with mice

Abstract

Keywords

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