TY - JOUR
T1 - Cigarette smoking and risk of large cell carcinoma of the lung
T2 - A case-control study in Uruguay
AU - De Stefani, Eduardo
AU - Deneo-Pellegrini, Hugo
AU - Boffetta, Paolo
AU - Brennan, Paul
AU - Ronco, Alvaro
AU - Gutiérrez, Luis Piñeyro
AU - Mendilaharsu, María
N1 - Funding Information:
This study was supported by a grant from International Agency for Research on Cancer, Lyon, France (ECE/98/17).
PY - 2004/3
Y1 - 2004/3
N2 - In the time period 1988-2000, a case-control study on large cell carcinoma of the lung was conducted in Montevideo, Uruguay. The study included 149 cases (139 men and 10 women) and 596 controls (556 men and 40 women) afflicted with diseases not related with tobacco smoking. Cases and controls were frequency matched on age, sex, residence and urban/rural status. According to our results, large cell carcinoma was strongly related with cigarette smoking (OR for heavy smokers 155.2, 95% CI: 30.6-786.1). Furthermore, all cases displayed higher risks for intensity compared with smoking duration. Smokers of black tobacco showed odds ratios (ORs) significantly higher than those presented by smokers of blond tobacco and smoking cessation displayed a reduction in risk of 95%, close to the risk of never smokers. Finally, filter use was not associated with any reduction in risk. It could be concluded that undifferentiated large cell carcinoma of the lung could be included among those lung tumors classified as Kreyberg I cancers.
AB - In the time period 1988-2000, a case-control study on large cell carcinoma of the lung was conducted in Montevideo, Uruguay. The study included 149 cases (139 men and 10 women) and 596 controls (556 men and 40 women) afflicted with diseases not related with tobacco smoking. Cases and controls were frequency matched on age, sex, residence and urban/rural status. According to our results, large cell carcinoma was strongly related with cigarette smoking (OR for heavy smokers 155.2, 95% CI: 30.6-786.1). Furthermore, all cases displayed higher risks for intensity compared with smoking duration. Smokers of black tobacco showed odds ratios (ORs) significantly higher than those presented by smokers of blond tobacco and smoking cessation displayed a reduction in risk of 95%, close to the risk of never smokers. Finally, filter use was not associated with any reduction in risk. It could be concluded that undifferentiated large cell carcinoma of the lung could be included among those lung tumors classified as Kreyberg I cancers.
KW - Air-cured
KW - Carcinoma
KW - Tumors
UR - https://www.scopus.com/pages/publications/1242283950
U2 - 10.1016/j.lungcan.2003.09.008
DO - 10.1016/j.lungcan.2003.09.008
M3 - Article
C2 - 15165084
AN - SCOPUS:1242283950
SN - 0169-5002
VL - 43
SP - 267
EP - 274
JO - Lung Cancer
JF - Lung Cancer
IS - 3
ER -