Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: Pooled analysis in the international head and neck cancer epidemiology consortium

Annah Wyss; Mia Hashibe; Shu Chun Chuang; Yuan Chin Amy Lee; Zuo Feng Zhang; Guo Pei Yu; Deborah M. Winn; Qingyi Wei; Erich M. Sturgis; Renato Talamini; Luigino Dal Maso; Neonila Szeszenia-Dabrowska; Elaine Smith; Oxana Shangina; Stephen M. Schwartz; Chu Chen; Stimson Schantz; Peter Rudnai; Mark P. Purdue; Jose Eluf-Neto; Joshua Muscat; Hal Morgenstern; Pedro Michaluart; Ana Menezes; Elena Matos; Ioan Nicolae Mates; Jolanta Lissowska; Fabio Levi; Philip Lazarus; Carlo La Vecchia; Sergio Koifman; Rolando Herrero; Richard B. Hayes; Silvia Franceschi; Victor Wünsch-Filho; Leticia Fernandez; Eleonora Fabianova; Alexander W. Daudt; Maria Paula Curado; Paolo Boffetta; Xavier Castellsague; Marcos Brasilino De Carvalho; Gabriella Cadoni; Stefania Boccia; Paul Brennan; Andrew F. Olshan

doi:10.1093/aje/kwt029

Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: Pooled analysis in the international head and neck cancer epidemiology consortium

Annah Wyss, Mia Hashibe, Shu Chun Chuang, Yuan Chin Amy Lee, Zuo Feng Zhang, Guo Pei Yu, Deborah M. Winn, Qingyi Wei, Erich M. Sturgis, Renato Talamini, Luigino Dal Maso, Neonila Szeszenia-Dabrowska, Elaine Smith, Oxana Shangina, Stephen M. Schwartz, Chu Chen, Stimson Schantz, Peter Rudnai, Mark P. Purdue, Jose Eluf-NetoJoshua Muscat, Hal Morgenstern, Pedro Michaluart, Ana Menezes, Elena Matos, Ioan Nicolae Mates, Jolanta Lissowska, Fabio Levi, Philip Lazarus, Carlo La Vecchia, Sergio Koifman, Rolando Herrero, Richard B. Hayes, Silvia Franceschi, Victor Wünsch-Filho, Leticia Fernandez, Eleonora Fabianova, Alexander W. Daudt, Maria Paula Curado, Paolo Boffetta, Xavier Castellsague, Marcos Brasilino De Carvalho, Gabriella Cadoni, Stefania Boccia, Paul Brennan, Andrew F. Olshan

Research output: Contribution to journal › Review article › peer-review

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Abstract

Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (P_trend ≤ 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers.

Original language	English
Pages (from-to)	679-690
Number of pages	12
Journal	American Journal of Epidemiology
Volume	178
Issue number	5
DOIs	https://doi.org/10.1093/aje/kwt029
State	Published - 1 Sep 2013

Keywords

head and neck neoplasms
smoking

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10.1093/aje/kwt029

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Wyss, A., Hashibe, M., Chuang, S. C., Lee, Y. C. A., Zhang, Z. F., Yu, G. P., Winn, D. M., Wei, Q., Sturgis, E. M., Talamini, R., Dal Maso, L., Szeszenia-Dabrowska, N., Smith, E., Shangina, O., Schwartz, S. M., Chen, C., Schantz, S., Rudnai, P., Purdue, M. P., ... Olshan, A. F. (2013). Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: Pooled analysis in the international head and neck cancer epidemiology consortium. American Journal of Epidemiology, 178(5), 679-690. https://doi.org/10.1093/aje/kwt029

@article{5e35b988c2764b79ba5c664b92c259af,

title = "Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: Pooled analysis in the international head and neck cancer epidemiology consortium",

abstract = "Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend ≤ 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers.",

keywords = "head and neck neoplasms, smoking",

author = "Annah Wyss and Mia Hashibe and Chuang, {Shu Chun} and Lee, {Yuan Chin Amy} and Zhang, {Zuo Feng} and Yu, {Guo Pei} and Winn, {Deborah M.} and Qingyi Wei and Sturgis, {Erich M.} and Renato Talamini and {Dal Maso}, Luigino and Neonila Szeszenia-Dabrowska and Elaine Smith and Oxana Shangina and Schwartz, {Stephen M.} and Chu Chen and Stimson Schantz and Peter Rudnai and Purdue, {Mark P.} and Jose Eluf-Neto and Joshua Muscat and Hal Morgenstern and Pedro Michaluart and Ana Menezes and Elena Matos and Mates, {Ioan Nicolae} and Jolanta Lissowska and Fabio Levi and Philip Lazarus and {La Vecchia}, Carlo and Sergio Koifman and Rolando Herrero and Hayes, {Richard B.} and Silvia Franceschi and Victor W{\"u}nsch-Filho and Leticia Fernandez and Eleonora Fabianova and Daudt, {Alexander W.} and Curado, {Maria Paula} and Paolo Boffetta and Xavier Castellsague and {De Carvalho}, {Marcos Brasilino} and Gabriella Cadoni and Stefania Boccia and Paul Brennan and Olshan, {Andrew F.}",

year = "2013",

month = sep,

day = "1",

doi = "10.1093/aje/kwt029",

language = "English",

volume = "178",

pages = "679--690",

journal = "American Journal of Epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "5",

}

Wyss, A, Hashibe, M, Chuang, SC, Lee, YCA, Zhang, ZF, Yu, GP, Winn, DM, Wei, Q, Sturgis, EM, Talamini, R, Dal Maso, L, Szeszenia-Dabrowska, N, Smith, E, Shangina, O, Schwartz, SM, Chen, C, Schantz, S, Rudnai, P, Purdue, MP, Eluf-Neto, J, Muscat, J, Morgenstern, H, Michaluart, P, Menezes, A, Matos, E, Mates, IN, Lissowska, J, Levi, F, Lazarus, P, La Vecchia, C, Koifman, S, Herrero, R, Hayes, RB, Franceschi, S, Wünsch-Filho, V, Fernandez, L, Fabianova, E, Daudt, AW, Curado, MP, Boffetta, P, Castellsague, X, De Carvalho, MB, Cadoni, G, Boccia, S, Brennan, P & Olshan, AF 2013, 'Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: Pooled analysis in the international head and neck cancer epidemiology consortium', American Journal of Epidemiology, vol. 178, no. 5, pp. 679-690. https://doi.org/10.1093/aje/kwt029

TY - JOUR

T1 - Cigarette, cigar, and pipe smoking and the risk of head and neck cancers

T2 - Pooled analysis in the international head and neck cancer epidemiology consortium

AU - Wyss, Annah

AU - Hashibe, Mia

AU - Chuang, Shu Chun

AU - Lee, Yuan Chin Amy

AU - Zhang, Zuo Feng

AU - Yu, Guo Pei

AU - Winn, Deborah M.

AU - Wei, Qingyi

AU - Sturgis, Erich M.

AU - Talamini, Renato

AU - Dal Maso, Luigino

AU - Szeszenia-Dabrowska, Neonila

AU - Smith, Elaine

AU - Shangina, Oxana

AU - Schwartz, Stephen M.

AU - Chen, Chu

AU - Schantz, Stimson

AU - Rudnai, Peter

AU - Purdue, Mark P.

AU - Eluf-Neto, Jose

AU - Muscat, Joshua

AU - Morgenstern, Hal

AU - Michaluart, Pedro

AU - Menezes, Ana

AU - Matos, Elena

AU - Mates, Ioan Nicolae

AU - Lissowska, Jolanta

AU - Levi, Fabio

AU - Lazarus, Philip

AU - La Vecchia, Carlo

AU - Koifman, Sergio

AU - Herrero, Rolando

AU - Hayes, Richard B.

AU - Franceschi, Silvia

AU - Wünsch-Filho, Victor

AU - Fernandez, Leticia

AU - Fabianova, Eleonora

AU - Daudt, Alexander W.

AU - Curado, Maria Paula

AU - Boffetta, Paolo

AU - Castellsague, Xavier

AU - De Carvalho, Marcos Brasilino

AU - Cadoni, Gabriella

AU - Boccia, Stefania

AU - Brennan, Paul

AU - Olshan, Andrew F.

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend ≤ 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers.

AB - Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend ≤ 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers.

KW - head and neck neoplasms

KW - smoking

UR - http://www.scopus.com/inward/record.url?scp=84883476216&partnerID=8YFLogxK

U2 - 10.1093/aje/kwt029

DO - 10.1093/aje/kwt029

M3 - Review article

C2 - 23817919

AN - SCOPUS:84883476216

SN - 0002-9262

VL - 178

SP - 679

EP - 690

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 5

ER -

Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: Pooled analysis in the international head and neck cancer epidemiology consortium

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