An apparent inverse relationship between smoking and Parkinson's disease prompted and investigation of the effect of chronic nicotine administration on dopaminergic and serotonergic receptors in rat brain. Nicotine, 0.8 mg/kg, was injected once daily, five times per week, for 6 weeks. In nucleus accumbens the Kd for [3H]domperidone was increased 2–4‐fold, and the Bmax was increased 1.5–2‐fold. No changes were observed in the binding of [3H]domperidone in caudateputamen or in that of [3H]ketanserin in frontal cortex. It is concluded that chronic nicotine administration may have a suppressant effect on central nervous system release of dopamine that in pre‐parkinsonian persons causes an aversion to the effects of smoking.
- Parkinson's disease
- dopamine receptors