Chronic, multi-contact, neural interface for deep brain stimulation

Angela Tooker, Teresa E. Madsen, Andrea Crowell, Kedar G. Shah, Sarah Felix, Helen S. Mayberg, Satinderpall Pannu, Donald G. Rainnie, Vanessa Tolosa

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Recent clinical studies show deep brain stimulation (DBS) as a promising therapy for the chronic treatment of major depression. Although an increasing number of studies have shown the clinical benefits of DBS in patients with major depressive disorder, little is known about the underlying mechanisms by which the treatment works. The neural interface described here consists of two multi-contact, polymer-based, microelectrode arrays that were specially-designed and fabricated. The first is for stimulation of the medial prefrontal cortex (mPFC) and the second is for recording local field potentials (LFPs) and event related potentials (ERPs) in the basolateral amygdala (BLA). Unlike conventional metal wire stimulating arrays, this stimulating array offers 144 spatial configurations, both monopolar and bipolar. We present here preliminary results involving stimulation of various contact points spanning the mPFC, with simultaneous recording from multiple contacts across the temporal lobe.

Original languageEnglish
Title of host publication2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Pages1198-1201
Number of pages4
DOIs
StatePublished - 2013
Externally publishedYes
Event2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 - San Diego, CA, United States
Duration: 6 Nov 20138 Nov 2013

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Conference

Conference2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Country/TerritoryUnited States
CitySan Diego, CA
Period6/11/138/11/13

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