TY - JOUR
T1 - CHRONIC LYMPHOCYTIC LEUKÆMIA
T2 - CLONAL ORIGIN IN A COMMITTED B-LYMPHOCYTE PROGENITOR
AU - Fialkow, Philip J.
AU - Najfeld, Vesna
AU - Lakshma Reddy, A.
AU - Singer, Jack
AU - Steinmann, Laura
N1 - Funding Information:
Having demonstrated that hypertension due to pyelo- nephritis scarring is associated with elevated P.R.A., we have now identified 8 hyperreninaemic patients among disturbance of the 100 normotensive children with scarred kidneys. is alsoThe- renin-angiotensin system demonstrated by a significantly less pronounced fall in P.R.A. with age in the pyelonephritic children than in normal children. Elevation of P.R.A. occurs not only in hypertensive patients: in some normotensive patients it may precede a rise in B.P. It may therefore prove useful in identifying children at risk of developing this complication. Although we suspect that the 8 hyperreninaemic nor- motensive children are those at risk of becoming hyper- tensive, longitudinal follow-up of all 100 children is required to confirm our hypothesis. We thank the nursing staff of the Shaftesbury Hospital and the Hos- pital for Sick Children for their assistance and interest, in particular Sister Fay and Staff Nurse Dayno. J.M.S. held an M.R.C. training fel- lowship. Financial support was provided by the National Kidney Research Fund and the Kidney Research Aid Fund. Requests for reprints should be addressed to J.M.S., Department of Child Health, Royal Manchester Children’s Hospital, Pendlebury, Manchester M271HA.
PY - 1978/8/26
Y1 - 1978/8/26
N2 - The glucose-6-phosphate dehydrogenase (G.-6-P.D.) types of isolated blood-cell populations and normal skin were determined in two patients with chronic lymphocytic leukæmia (C.L.L.) who were heterozygous at the G.-6-P.D. locus. Normal tissues from each patient manifested both A and B G.-6-P.D. types, but the C.L.L. B-lymphocyte preparation from one patient showed only a single enzyme type, and from the other patient it showed 95% activity of one G.-6-P.D. type. These observations confirm the supposition based on immunoglobulin-marker data that at the time of study C.L.L. has a clonal origin. In contrast to the B lymphocytes, granulocytes, erythrocytes, platelets, and T lymphocytes displayed both enzyme types in proportions similar to those found in skin. These findings indicate that C.L.L. involves committed B-lymphocyte progenitors. Thus, the disease stands in contrast to chronic myelocytic leukæmia and other myeloproliferative syndromes, all of which involve multipotent hæmopoietic stem cells.
AB - The glucose-6-phosphate dehydrogenase (G.-6-P.D.) types of isolated blood-cell populations and normal skin were determined in two patients with chronic lymphocytic leukæmia (C.L.L.) who were heterozygous at the G.-6-P.D. locus. Normal tissues from each patient manifested both A and B G.-6-P.D. types, but the C.L.L. B-lymphocyte preparation from one patient showed only a single enzyme type, and from the other patient it showed 95% activity of one G.-6-P.D. type. These observations confirm the supposition based on immunoglobulin-marker data that at the time of study C.L.L. has a clonal origin. In contrast to the B lymphocytes, granulocytes, erythrocytes, platelets, and T lymphocytes displayed both enzyme types in proportions similar to those found in skin. These findings indicate that C.L.L. involves committed B-lymphocyte progenitors. Thus, the disease stands in contrast to chronic myelocytic leukæmia and other myeloproliferative syndromes, all of which involve multipotent hæmopoietic stem cells.
UR - https://www.scopus.com/pages/publications/0018075953
U2 - 10.1016/S0140-6736(78)91444-7
DO - 10.1016/S0140-6736(78)91444-7
M3 - Article
C2 - 79806
AN - SCOPUS:0018075953
SN - 0140-6736
VL - 312
SP - 444
EP - 446
JO - The Lancet
JF - The Lancet
IS - 8087
ER -