Chronic lung disease secondary to ammonia inhalation injury: A report on three cases

Rafael E. De La Hoz, Donald P. Schlueter, William N. Rom

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Inhalation of highly hydrosoluble toxicants, like ammonia, can be associated with chronic lung diseases, which have been partially characterized. We present the cases of three patients who were evaluated 2 years after massive exposure to ammonia in occupational settings. They presented with chronic dyspnea, and clinical pictures consistent with restrictive lung dysfunction, obstructive lung disease, and bronchial hyper- reactivity and small airways disease, respectively. The findings in 94 reported cases of inhalation injury due to massive exposure to ammonia are reviewed; in 35 cases follow-up for at least 1 year was available. The range of chronic pulmonary diseases associated with ammonia inhalation injury is reviewed, and suggestions for appropriate diagnostic evaluation are made.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalAmerican Journal of Industrial Medicine
Issue number2
StatePublished - Feb 1996
Externally publishedYes


  • ammonia
  • asthma
  • lung diseases
  • occupational diseases


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