TY - JOUR
T1 - Chronic administration of three neuroleptics
T2 - Effects of behavioral supersensitivity mediated by two different brain regions in the rat
AU - Halperin, R.
AU - Guerin, J. J.
AU - Davis, K. L.
N1 - Funding Information:
The magnitude of the pharmacologically elicited stereotypic and locomotor responses appears to reflect the degree of DA-receptor sensitivity in the striatum and nucleus acc~nbens. Injection of haloperidol to the striatum has been shown to cause a dose-dependent attenuation of stereotypy produced by systemic injection of the DA-agonist apomorphine (8). Similarly, injection of haloperidol to the nucleus accumbens causes a dose-dependent attenuation of locomotion in response to a previous DA injection to the same brain site (8). Furthermore, manipulations which enhance DA-receptor sensitivity also result in an increased iThis work was supported by the Schizophrenia Biological Research Center and the Medical Research Service, funded by the Veterans Administration and a grant from Sandoz, Inc.
PY - 1983/8/8
Y1 - 1983/8/8
N2 - This investigation assessed the relative abilities of three neuroleptics to supersensitize behaviors mediated by the nigrostriatal and mesolimbic dopamine (DA) systems. Rats were treated with either haloperidol, thioridazine, fluotracen or vehicle for 21 days. Stereotypy, in response to DA injection to the striatum, or locomotor activity, in response to DA injection to the nucleus accumbens, were measured after the termination of drug treatment. Pre-treatment with haloperidol enhanced both behavioral responses to central DA injection, while pre-treatment with thioridazine did not enhance either behavior. Pre-treatment with fluotracen enhanced the locomotor response to DA injection to the nucleus accumbens, but did not alter stereotypy after DA injection to the striatum. Neuroleptics differ in their ability to supersensitize the same DA-related behavior, and act selectively to supersensitize behaviors mediated by different DA systems.
AB - This investigation assessed the relative abilities of three neuroleptics to supersensitize behaviors mediated by the nigrostriatal and mesolimbic dopamine (DA) systems. Rats were treated with either haloperidol, thioridazine, fluotracen or vehicle for 21 days. Stereotypy, in response to DA injection to the striatum, or locomotor activity, in response to DA injection to the nucleus accumbens, were measured after the termination of drug treatment. Pre-treatment with haloperidol enhanced both behavioral responses to central DA injection, while pre-treatment with thioridazine did not enhance either behavior. Pre-treatment with fluotracen enhanced the locomotor response to DA injection to the nucleus accumbens, but did not alter stereotypy after DA injection to the striatum. Neuroleptics differ in their ability to supersensitize the same DA-related behavior, and act selectively to supersensitize behaviors mediated by different DA systems.
UR - https://www.scopus.com/pages/publications/0020597713
U2 - 10.1016/0024-3205(83)90134-0
DO - 10.1016/0024-3205(83)90134-0
M3 - Article
C2 - 6684202
AN - SCOPUS:0020597713
SN - 0024-3205
VL - 33
SP - 585
EP - 592
JO - Life Sciences
JF - Life Sciences
IS - 6
ER -