Chronic active Epstein-Bar virus infection complicated by pulmonary artery hypertension

Yukiko Misaki; Daisuke Minakata; Tatsuro Ibe; Ayumi Gomyo; Kazuki Yoshimura; Shun ichi Kimura; Yuhei Nakamura; Masakatsu Kawamura; Shunto Kawamura; Junko Takeshita; Nozomu Yoshino; Shimpei Matsumi; Yu Akahoshi; Masaharu Tamaki; Machiko Kusuda; Kazuaki Kameda; Hidenori Wada; Koji Kawamura; Miki Sato; Kiriko Terasako-Saito; Aki Tanihara; Kaoru Hatano; Hideki Nakasone; Ken ichi Imadome; Hiroshi Wada; Shinichi Kako; Hisashi Oshiro; Akira Tanaka; Yoshinobu Kanda

doi:10.1016/j.jiac.2022.10.013

Chronic active Epstein-Bar virus infection complicated by pulmonary artery hypertension

Yukiko Misaki, Daisuke Minakata, Tatsuro Ibe, Ayumi Gomyo, Kazuki Yoshimura, Shun ichi Kimura, Yuhei Nakamura, Masakatsu Kawamura, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Shimpei Matsumi, Yu Akahoshi, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Hidenori Wada, Koji Kawamura, Miki Sato, Kiriko Terasako-SaitoAki Tanihara, Kaoru Hatano, Hideki Nakasone, Ken ichi Imadome, Hiroshi Wada, Shinichi Kako, Hisashi Oshiro, Akira Tanaka, Yoshinobu Kanda

Research output: Contribution to journal › Article › peer-review

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Abstract

Chronic active Epstein-Bar virus infection (CAEBV) is known to cause various symptoms. Although pulmonary artery hypertension (PAH) has been reported as a cardiovascular complication of CAEBV, the mechanisms of PAH and the effects of treatment have not been fully elucidated. We experienced 4 adult patients with CAEBV complicated by PAH. All of them received treatment for PAH with a vasodilator followed by chemotherapy with or without allogeneic hematopoietic cell transplantation for CAEBV. In all of these patients, the transtricuspid pressure gradient improved under treatment with vasodilator, and further improvement was observed under treatment for CAEBV in 3 patients. Autopsy was performed in 2 patients, which revealed EBER-positive cells and a change in the pulmonary artery at each stage in the pathology. In conclusion, EBV-infected cells can cause vasculitis and finally PAH. However, PAH complicated with CAEBV can be improved by PAH medication and treatment of CAEBV.

Original language	English
Pages (from-to)	212-218
Number of pages	7
Journal	Journal of Infection and Chemotherapy
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.jiac.2022.10.013
State	Published - Feb 2023
Externally published	Yes

Keywords

Adult patients
CAEBV
CAEBV complication
PAH
PH

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10.1016/j.jiac.2022.10.013

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Misaki, Y., Minakata, D., Ibe, T., Gomyo, A., Yoshimura, K., Kimura, S. I., Nakamura, Y., Kawamura, M., Kawamura, S., Takeshita, J., Yoshino, N., Matsumi, S., Akahoshi, Y., Tamaki, M., Kusuda, M., Kameda, K., Wada, H., Kawamura, K., Sato, M., ... Kanda, Y. (2023). Chronic active Epstein-Bar virus infection complicated by pulmonary artery hypertension. Journal of Infection and Chemotherapy, 29(2), 212-218. https://doi.org/10.1016/j.jiac.2022.10.013

@article{179cc6ba1a6742828fb619de174a75b0,

title = "Chronic active Epstein-Bar virus infection complicated by pulmonary artery hypertension",

abstract = "Chronic active Epstein-Bar virus infection (CAEBV) is known to cause various symptoms. Although pulmonary artery hypertension (PAH) has been reported as a cardiovascular complication of CAEBV, the mechanisms of PAH and the effects of treatment have not been fully elucidated. We experienced 4 adult patients with CAEBV complicated by PAH. All of them received treatment for PAH with a vasodilator followed by chemotherapy with or without allogeneic hematopoietic cell transplantation for CAEBV. In all of these patients, the transtricuspid pressure gradient improved under treatment with vasodilator, and further improvement was observed under treatment for CAEBV in 3 patients. Autopsy was performed in 2 patients, which revealed EBER-positive cells and a change in the pulmonary artery at each stage in the pathology. In conclusion, EBV-infected cells can cause vasculitis and finally PAH. However, PAH complicated with CAEBV can be improved by PAH medication and treatment of CAEBV.",

keywords = "Adult patients, CAEBV, CAEBV complication, PAH, PH",

author = "Yukiko Misaki and Daisuke Minakata and Tatsuro Ibe and Ayumi Gomyo and Kazuki Yoshimura and Kimura, {Shun ichi} and Yuhei Nakamura and Masakatsu Kawamura and Shunto Kawamura and Junko Takeshita and Nozomu Yoshino and Shimpei Matsumi and Yu Akahoshi and Masaharu Tamaki and Machiko Kusuda and Kazuaki Kameda and Hidenori Wada and Koji Kawamura and Miki Sato and Kiriko Terasako-Saito and Aki Tanihara and Kaoru Hatano and Hideki Nakasone and Imadome, {Ken ichi} and Hiroshi Wada and Shinichi Kako and Hisashi Oshiro and Akira Tanaka and Yoshinobu Kanda",

note = "Publisher Copyright: {\textcopyright} 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases",

year = "2023",

month = feb,

doi = "10.1016/j.jiac.2022.10.013",

language = "English",

volume = "29",

pages = "212--218",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

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number = "2",

}

Misaki, Y, Minakata, D, Ibe, T, Gomyo, A, Yoshimura, K, Kimura, SI, Nakamura, Y, Kawamura, M, Kawamura, S, Takeshita, J, Yoshino, N, Matsumi, S, Akahoshi, Y, Tamaki, M, Kusuda, M, Kameda, K, Wada, H, Kawamura, K, Sato, M, Terasako-Saito, K, Tanihara, A, Hatano, K, Nakasone, H, Imadome, KI, Wada, H, Kako, S, Oshiro, H, Tanaka, A & Kanda, Y 2023, 'Chronic active Epstein-Bar virus infection complicated by pulmonary artery hypertension', Journal of Infection and Chemotherapy, vol. 29, no. 2, pp. 212-218. https://doi.org/10.1016/j.jiac.2022.10.013

TY - JOUR

T1 - Chronic active Epstein-Bar virus infection complicated by pulmonary artery hypertension

AU - Misaki, Yukiko

AU - Minakata, Daisuke

AU - Ibe, Tatsuro

AU - Gomyo, Ayumi

AU - Yoshimura, Kazuki

AU - Kimura, Shun ichi

AU - Nakamura, Yuhei

AU - Kawamura, Masakatsu

AU - Kawamura, Shunto

AU - Takeshita, Junko

AU - Yoshino, Nozomu

AU - Matsumi, Shimpei

AU - Akahoshi, Yu

AU - Tamaki, Masaharu

AU - Kusuda, Machiko

AU - Kameda, Kazuaki

AU - Wada, Hidenori

AU - Kawamura, Koji

AU - Sato, Miki

AU - Terasako-Saito, Kiriko

AU - Tanihara, Aki

AU - Hatano, Kaoru

AU - Nakasone, Hideki

AU - Imadome, Ken ichi

AU - Wada, Hiroshi

AU - Kako, Shinichi

AU - Oshiro, Hisashi

AU - Tanaka, Akira

AU - Kanda, Yoshinobu

PY - 2023/2

Y1 - 2023/2

N2 - Chronic active Epstein-Bar virus infection (CAEBV) is known to cause various symptoms. Although pulmonary artery hypertension (PAH) has been reported as a cardiovascular complication of CAEBV, the mechanisms of PAH and the effects of treatment have not been fully elucidated. We experienced 4 adult patients with CAEBV complicated by PAH. All of them received treatment for PAH with a vasodilator followed by chemotherapy with or without allogeneic hematopoietic cell transplantation for CAEBV. In all of these patients, the transtricuspid pressure gradient improved under treatment with vasodilator, and further improvement was observed under treatment for CAEBV in 3 patients. Autopsy was performed in 2 patients, which revealed EBER-positive cells and a change in the pulmonary artery at each stage in the pathology. In conclusion, EBV-infected cells can cause vasculitis and finally PAH. However, PAH complicated with CAEBV can be improved by PAH medication and treatment of CAEBV.

AB - Chronic active Epstein-Bar virus infection (CAEBV) is known to cause various symptoms. Although pulmonary artery hypertension (PAH) has been reported as a cardiovascular complication of CAEBV, the mechanisms of PAH and the effects of treatment have not been fully elucidated. We experienced 4 adult patients with CAEBV complicated by PAH. All of them received treatment for PAH with a vasodilator followed by chemotherapy with or without allogeneic hematopoietic cell transplantation for CAEBV. In all of these patients, the transtricuspid pressure gradient improved under treatment with vasodilator, and further improvement was observed under treatment for CAEBV in 3 patients. Autopsy was performed in 2 patients, which revealed EBER-positive cells and a change in the pulmonary artery at each stage in the pathology. In conclusion, EBV-infected cells can cause vasculitis and finally PAH. However, PAH complicated with CAEBV can be improved by PAH medication and treatment of CAEBV.

KW - Adult patients

KW - CAEBV

KW - CAEBV complication

KW - PAH

KW - PH

UR - http://www.scopus.com/inward/record.url?scp=85141493606&partnerID=8YFLogxK

U2 - 10.1016/j.jiac.2022.10.013

DO - 10.1016/j.jiac.2022.10.013

M3 - Article

C2 - 36374666

AN - SCOPUS:85141493606

SN - 1341-321X

VL - 29

SP - 212

EP - 218

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 2

ER -

Chronic active Epstein-Bar virus infection complicated by pulmonary artery hypertension

Abstract

Keywords

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