Chromosome Abnormality in Offspring of LSD User: D Trisomy With D/D Translocation

Lillian Y. Hsu; Lotte Strauss; Kurt Hirschhorn

doi:10.1001/jama.1970.03170060051010

Chromosome Abnormality in Offspring of LSD User: D Trisomy With D/D Translocation

Lillian Y. Hsu
, Lotte Strauss
, Kurt Hirschhorn

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Congenital abnormalities compatible with D₁-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.

Original language	English
Pages (from-to)	987-990
Number of pages	4
Journal	JAMA - Journal of the American Medical Association
Volume	211
Issue number	6
DOIs	https://doi.org/10.1001/jama.1970.03170060051010
State	Published - 9 Feb 1970
Externally published	Yes

Access to Document

10.1001/jama.1970.03170060051010

Cite this

@article{f1046dcf04944c59b96fbfec2127f877,

title = "Chromosome Abnormality in Offspring of LSD User: D Trisomy With D/D Translocation",

abstract = "Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.",

author = "Hsu, \{Lillian Y.\} and Lotte Strauss and Kurt Hirschhorn",

year = "1970",

month = feb,

day = "9",

doi = "10.1001/jama.1970.03170060051010",

language = "English",

volume = "211",

pages = "987--990",

journal = "JAMA - Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "6",

}

TY - JOUR

T1 - Chromosome Abnormality in Offspring of LSD User

T2 - D Trisomy With D/D Translocation

AU - Hsu, Lillian Y.

AU - Strauss, Lotte

AU - Hirschhorn, Kurt

PY - 1970/2/9

Y1 - 1970/2/9

N2 - Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.

AB - Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.

UR - https://www.scopus.com/pages/publications/0014937720

U2 - 10.1001/jama.1970.03170060051010

DO - 10.1001/jama.1970.03170060051010

M3 - Article

C2 - 5467289

AN - SCOPUS:0014937720

SN - 0098-7484

VL - 211

SP - 987

EP - 990

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

IS - 6

ER -

Chromosome Abnormality in Offspring of LSD User: D Trisomy With D/D Translocation

Abstract

Access to Document

Fingerprint

Cite this