TY - JOUR
T1 - Chromosome 21 rearrangement in acute biphenotypic leukemia
AU - Theodossiou, Chris
AU - Scalise, Angela
AU - Silverman, Lewis
AU - Najfeld, Vesna
PY - 1992/11
Y1 - 1992/11
N2 - A patient with myelodysplastic syndrome (MDS) and a 47,XY,+21 karyotype at diagnosis, was documented to have a clonal chromosome 21 rearrangement, i(21q), four months before transformation to acute biphenotypic leukemia. For 4 months after transformation, isochromosome 21 persisted while the patient was receiving treatment with zidovudine. Vitamin D3 was added to zidovudine for an additional month, during which time the trisomy 21 clone reappeared as the predominant cell population. The unique aspects of this patient are the atypical evolution of chromosome 21, the transformation to biphenotypic leukemia, and the occurrence of i(21q) associated with biphenotypic leukemia evolving from an MDS.
AB - A patient with myelodysplastic syndrome (MDS) and a 47,XY,+21 karyotype at diagnosis, was documented to have a clonal chromosome 21 rearrangement, i(21q), four months before transformation to acute biphenotypic leukemia. For 4 months after transformation, isochromosome 21 persisted while the patient was receiving treatment with zidovudine. Vitamin D3 was added to zidovudine for an additional month, during which time the trisomy 21 clone reappeared as the predominant cell population. The unique aspects of this patient are the atypical evolution of chromosome 21, the transformation to biphenotypic leukemia, and the occurrence of i(21q) associated with biphenotypic leukemia evolving from an MDS.
UR - http://www.scopus.com/inward/record.url?scp=0027100469&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(92)90323-Z
DO - 10.1016/0165-4608(92)90323-Z
M3 - Article
C2 - 1360869
AN - SCOPUS:0027100469
SN - 0165-4608
VL - 64
SP - 56
EP - 59
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -